INT181348

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 19.55
Pain Relevance 6.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
T-lymphocytes 4
platelets 3
plasma 2
macrophages 2
endothelial cells 2
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 370 100.00 Very High Very High Very High
chemokine 891 99.96 Very High Very High Very High
Inflammation 532 99.18 Very High Very High Very High
Central nervous system 315 99.14 Very High Very High Very High
Morphine 156 99.06 Very High Very High Very High
Multiple sclerosis 360 96.80 Very High Very High Very High
Inflammatory response 49 96.00 Very High Very High Very High
Neuropeptide 2 95.60 Very High Very High Very High
opiate 36 95.36 Very High Very High Very High
imagery 9 93.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 575 99.18 Very High Very High Very High
Central Nervous System Disease 288 99.14 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 100 97.84 Very High Very High Very High
Demyelinating Disease 468 96.80 Very High Very High Very High
Malaria 432 96.64 Very High Very High Very High
Amyloid Plaque 7 96.60 Very High Very High Very High
Cerebral Malaria 351 96.36 Very High Very High Very High
Multiple Sclerosis 474 96.20 Very High Very High Very High
Infection 485 94.32 High High
Disease 239 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL5 is secreted by epithelial cells, macrophages, fibroblasts, platelets, and activated T cells [18].
Localization (secreted) of CCL5 in fibroblasts
1) Confidence 0.65 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.68 Pain Relevance 0.20
Furthermore, activated T-lymphocytes, platelets and endothelial cells release large amount of RANTES 3–5 days after activation, giving this chemokine a unique role in the generation, maintenance and prolongation of immune and inflammatory response [23].
Localization (release) of RANTES 3 in T-lymphocytes associated with chemokine and inflammatory response
2) Confidence 0.60 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.61 Pain Relevance 0.21
To determine whether RANTES and its receptor interactions were localized (brain) or systemic (peripheral blood), plasma RANTES levels were determined in P. yoelii 17XL-infected and control mice, using RANTES specific ELISA (Biosource International, Camarillo, CA, USA) according to the manufacturer's specifications.
Localization (localized) of RANTES in plasma
3) Confidence 0.60 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.05 Pain Relevance 0.05
Since RANTES may be released by platelets during serum collection, heparinized blood was collected, centrifuged at 13,000 rpm for 10 minutes to obtain plasma samples, and subsequently stored at -20°C until used.
Localization (released) of RANTES in plasma
4) Confidence 0.60 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0 Pain Relevance 0.04
In humans, there are 27 CC chemokines, most of which including CCL2, CCL7, CCL11, CCL8, CCL13, CCL1, CCL5, CCL16, CCL14, CCL15, CCL23, CCL18, CCL3 and CCL4, respectively, are encoded as a cluster within chromosome 17q11.
Localization (including) of CCL5 associated with chemokine
5) Confidence 0.55 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.50 Pain Relevance 0.72
These T cells showed an increased migration towards CCL3 and CCL5, suggesting a functional significance of the altered receptor expression [42,52].
Localization (migration) of CCL5 in T cells
6) Confidence 0.55 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.80 Pain Relevance 0.26
Additionally, activated lymphocytes, platelets and endothelial cells release large quantities of RANTES, thus suggesting a unique role for RANTES in the generation and maintenance of the malaria-induced inflammatory response.
Localization (release) of RANTES in endothelial cells associated with malaria and inflammatory response
7) Confidence 0.52 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.97 Pain Relevance 0.25
Western blot analysis revealed that brain tissue transcripts of RANTES were actually translated into protein, and were significantly up-regulated (p = 0.046 for day 4 and p < 0.034 for day six and day eight post-infection) in infected mice (Figure 3A).
Localization (transcripts) of RANTES in brain associated with infection
8) Confidence 0.52 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.01 Pain Relevance 0.07
[CCL4]), and to lesser degrees, T lymphocytes and NK cells (MCP and MIP chemokines, regulated upon activation normal T cell expressed and secreted cytokine [RANTES]) or occasionally other cell types (e.g. eosinophil chemotactic protein – eotactin [CCL11]) into inflammatory lesions of MS.


Localization (cell expressed and secreted) of RANTES in T cell associated with chemokine, multiple sclerosis, inflammation and cytokine
9) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.62 Pain Relevance 0.65
Thus, the functional involvement of CCL chemokines during EAE is not only restricted to a well orchestrated recruitment of dendritic cells, monocytes, macrophages, T effector and regulatory cells into the CNS, but also includes a temporal and spatial regulation of TH1 (CCL3, CCL5) or TH2 (CCL2, CCL22) polarization, and monocyte, macrophage and microglial activation (CCL1, CCL2, CCL7, CCL8).
Localization (regulation) of CCL5 in macrophages associated with chemokine, multiple sclerosis and central nervous system
10) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.08 Pain Relevance 0.23
Among them are macrophage inflammatory protein (MIP), MCP, CCL5 (also known as RANTES [regulated on activation, normal T-cell expressed and secreted]) and IL-8.
Localization (secreted) of RANTES in T-cell associated with inflammation
11) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.54 Pain Relevance 0.35
CCL5 is secreted by epithelial cells, macrophages, fibroblasts, platelets, and activated T cells [18].
Localization (secreted) of CCL5 in epithelial cells
12) Confidence 0.22 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.68 Pain Relevance 0.20
CCL5 is secreted by epithelial cells, macrophages, fibroblasts, platelets, and activated T cells [18].
Localization (secreted) of CCL5 in macrophages
13) Confidence 0.22 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.68 Pain Relevance 0.20
CCL5 is secreted by epithelial cells, macrophages, fibroblasts, platelets, and activated T cells [18].
Localization (secreted) of CCL5 in platelets
14) Confidence 0.22 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.68 Pain Relevance 0.20
Furthermore, activated T-lymphocytes, platelets and endothelial cells release large amount of RANTES 3–5 days after activation, giving this chemokine a unique role in the generation, maintenance and prolongation of immune and inflammatory response [23].
Localization (release) of RANTES 3 in endothelial cells associated with chemokine and inflammatory response
15) Confidence 0.20 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.61 Pain Relevance 0.21
Furthermore, activated T-lymphocytes, platelets and endothelial cells release large amount of RANTES 3–5 days after activation, giving this chemokine a unique role in the generation, maintenance and prolongation of immune and inflammatory response [23].
Localization (release) of RANTES 3 in platelets associated with chemokine and inflammatory response
16) Confidence 0.20 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.61 Pain Relevance 0.21
Additionally, activated lymphocytes, platelets and endothelial cells release large quantities of RANTES, thus suggesting a unique role for RANTES in the generation and maintenance of the malaria-induced inflammatory response.
Localization (release) of RANTES in lymphocytes associated with malaria and inflammatory response
17) Confidence 0.18 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.97 Pain Relevance 0.25
Additionally, activated lymphocytes, platelets and endothelial cells release large quantities of RANTES, thus suggesting a unique role for RANTES in the generation and maintenance of the malaria-induced inflammatory response.
Localization (release) of RANTES in platelets associated with malaria and inflammatory response
18) Confidence 0.18 Published 2005 Journal Malar J Section Abstract Doc Link PMC1343570 Disease Relevance 0.97 Pain Relevance 0.25
Interestingly, we previously found that morphine could exacerbate Tat-induced increases in the release of RANTES and MCP-1, but not TNF-?
Localization (release) of RANTES associated with morphine
19) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.09 Pain Relevance 0.36
and chemokines (e.g., CCL2/MCP-1, CCL5/RANTES, and CCL3/MIP-1 ?)
Localization (e.g.) of RANTES associated with chemokine
20) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.99 Pain Relevance 1.05

General Comments

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