INT18135

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Context Info
Confidence 0.17
First Reported 1985
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.15
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Stmn1) cytosol (Stmn1) cytoskeleton (Stmn1)
intracellular (Stmn1) cytoplasm (Stmn1)
Stmn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
fortral 12 99.82 Very High Very High Very High
Clonidine 8 98.36 Very High Very High Very High
cerebral cortex 2 97.84 Very High Very High Very High
agonist 2 97.12 Very High Very High Very High
withdrawal 2 95.32 Very High Very High Very High
Morphine 2 94.40 High High
midbrain 3 94.12 High High
Thalamus 3 93.68 High High
narcan 10 89.92 High High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 2 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in opioid receptors (Op-R) caused by repeated administration of pentazocine and the effect of concomitant clonidine were investigated.
Regulation (changes) of Op-R associated with fortral, opioid receptor and clonidine
1) Confidence 0.17 Published 1985 Journal Acta Med. Okayama Section Abstract Doc Link 2992233 Disease Relevance 0.06 Pain Relevance 1.04
The pentazocine-induced changes in Op-R were abolished by the concurrent use of clonidine, an alpha-adrenergic agonist, which has been shown to relieve the withdrawal symptoms of morphine.
Regulation (changes) of Op-R associated with fortral, agonist, opioid receptor, withdrawal, morphine and clonidine
2) Confidence 0.15 Published 1985 Journal Acta Med. Okayama Section Abstract Doc Link 2992233 Disease Relevance 0.10 Pain Relevance 1.29
Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.
Regulation (regulated) of Op-R
3) Confidence 0.14 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1965518 Disease Relevance 0 Pain Relevance 0.90

General Comments

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