INT181355

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.37
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
macrophage 4
monocyte 4
Leukocytes 4
retinas 2
astrocyte 2
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 252 100.00 Very High Very High Very High
chemokine 178 100.00 Very High Very High Very High
Central nervous system 164 100.00 Very High Very High Very High
ischemia 19 99.20 Very High Very High Very High
corticosteroid 5 97.88 Very High Very High Very High
Multiple sclerosis 126 93.56 High High
Inflammatory response 28 90.40 High High
imagery 7 87.40 High High
metalloproteinase 130 84.96 Quite High
cytokine 103 84.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 254 100.00 Very High Very High Very High
Central Nervous System Disease 96 100.00 Very High Very High Very High
Atherosclerosis 37 99.84 Very High Very High Very High
Targeted Disruption 63 99.76 Very High Very High Very High
Sprains And Strains 98 99.58 Very High Very High Very High
Recurrence 32 99.24 Very High Very High Very High
Brain Hemorrhage 5 99.20 Very High Very High Very High
Multiple Sclerosis 260 98.82 Very High Very High Very High
Pneumonia 32 98.68 Very High Very High Very High
Disease 70 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of well defined changes in the CCL2, CCL3 and CCL5 levels in the CSF during relapses, most investigators observed no differences in various clinical forms of the disease [56,61,64,66].
Neg (exception) Regulation (changes) of Gene_expression (levels) of CCL2 associated with disease and recurrence
1) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.34 Pain Relevance 0.76
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Regulation (regulated) of Gene_expression (expression) of Ccl2 in retinas
2) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.97 Pain Relevance 0.35
In addition, both siRNA treatments showed a significant reduction of gene expression of Ccl2, an active biomaker of inflammation, which was up-regulated in bleomycin stimulated mice (Figure 5B).


Regulation (regulated) of Gene_expression (expression) of Ccl2 associated with inflammation
3) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.62 Pain Relevance 0.17
Although we did not detect any changes in Vegf expression, chemoattractant molecules monocyte chemoattractant protein-1 (MCP-1/Ccl2) and Defb15, both potent inducers of EPC mobilization and recruitment [33, 34], were independently confirmed by quantitative PCR (Fig. 6F).
Neg (not) Regulation (changes) of Gene_expression (expression) of Ccl2 in monocyte
4) Confidence 0.42 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.44 Pain Relevance 0.10
Although we did not detect any changes in Vegf expression, chemoattractant molecules monocyte chemoattractant protein-1 (MCP-1/Ccl2) and Defb15, both potent inducers of EPC mobilization and recruitment [33, 34], were independently confirmed by quantitative PCR (Fig. 6F).
Neg (not) Regulation (changes) of Gene_expression (expression) of monocyte chemoattractant protein-1 in monocyte
5) Confidence 0.36 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.44 Pain Relevance 0.10
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Regulation (effect) of Gene_expression (levels) of CCL2 in lung
6) Confidence 0.31 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.44 Pain Relevance 0.25
More recently, Elhofy et al [28] examined TH1 lymphocytes in a PLP-induced EAE model using a transgenic mouse strain that constitutively expressed low CCL2 levels in the CNS under the control of the astrocyte-specific glial fibrillary acidic protein promoter.
Regulation (under) of Gene_expression (expressed) of CCL2 in astrocyte associated with targeted disruption, multiple sclerosis, central nervous system and sprains and strains
7) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.60 Pain Relevance 0.33
A similar trend was found for protein and gene expression levels of MCP-1 and TNF-?
Regulation (found) of Gene_expression (expression) of MCP-1
8) Confidence 0.21 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.07 Pain Relevance 0
Overall, there were significant effects from both mechanical ventilation and genotype on expression of KC/CXCL1, MCP1/CCL2, MIP1?
Regulation (effects) of Gene_expression (expression) of CCL2
9) Confidence 0.19 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.10 Pain Relevance 0.12
Leukocytes spontaneously accumulate in the perivascular space in the CNS of transgenic mice which express the chemokine CCL2 under control of a truncated MBP promoter [19].
Regulation (control) of Gene_expression (express) of CCL2 in Leukocytes associated with targeted disruption, chemokine and central nervous system
10) Confidence 0.18 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.80 Pain Relevance 0.48
Leukocytes spontaneously accumulate in the perivascular space in the CNS of transgenic mice which express the chemokine CCL2 under control of a truncated MBP promoter [19].
Regulation (under) of Gene_expression (express) of CCL2 in Leukocytes associated with targeted disruption, chemokine and central nervous system
11) Confidence 0.18 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.75 Pain Relevance 0.48
Ezetimibe decreased macrophage content and monocyte chemoattractant protein 1 (MCP-1) expression in atherosclerotic lesions and reduced the increased activity of nuclear factor-?
Regulation (content) of Gene_expression (expression) of monocyte chemoattractant protein 1 in macrophage associated with atherosclerosis
12) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.41 Pain Relevance 0.04
Ezetimibe decreased macrophage content and monocyte chemoattractant protein 1 (MCP-1) expression in atherosclerotic lesions and reduced the increased activity of nuclear factor-?
Regulation (content) of Gene_expression (expression) of MCP-1 in macrophage associated with atherosclerosis
13) Confidence 0.06 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.41 Pain Relevance 0.04

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