INT181356

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.30
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
T cells 4
cervix 3
macrophages 2
lymphocytes 2
limb muscle 2
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 447 100.00 Very High Very High Very High
Multiple sclerosis 180 99.40 Very High Very High Very High
Inflammation 207 90.08 High High
cytokine 120 82.32 Quite High
Central nervous system 150 81.60 Quite High
agonist 1 73.20 Quite High
Inflammatory response 10 64.56 Quite High
corticosteroid 6 50.64 Quite High
Neuritis 18 40.28 Quite Low
imagery 3 21.68 Low Low
Disease Link Frequency Relevance Heat
Infection 181 99.98 Very High Very High Very High
Malaria 96 99.78 Very High Very High Very High
Recurrence 48 99.58 Very High Very High Very High
Demyelinating Disease 234 99.40 Very High Very High Very High
Chlamydia Infection 203 98.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 84 98.00 Very High Very High Very High
Adhesions 33 92.92 High High
Brain Disease 4 92.32 High High
INFLAMMATION 218 90.08 High High
Sepsis 26 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, increased expression of the CCR5 ligand, MIP-1a/CCL3, in humans (as a result of gene duplication) provides protection from HIV acquisition (Gonzalez et al 2005).
Positive_regulation (increased) of Gene_expression (expression) of CCR5 associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.66 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.54 Pain Relevance 0.20
mRNA expression during early stages of infection at inductive sites (i.e., spleen and ILN) preceded CCR5 expression at effectors sites (i.e., fallopian tube(s), uterus, and cervix).
Positive_regulation (preceded) of Gene_expression (expression) of CCR5 in cervix associated with infection
2) Confidence 0.62 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.04 Pain Relevance 0.15
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Positive_regulation (upregulated) of Gene_expression (expressions) of CCR5 in brains associated with chemokine
3) Confidence 0.57 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.55 Pain Relevance 0.41
The aberrant migration of T cells towards CCL3 and CCL5 was related to the increased expression of the CCR5 receptor, and could be blocked by anti-CCR5 antibodies.
Positive_regulation (increased) of Gene_expression (expression) of CCR5 receptor in T cells
4) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.94 Pain Relevance 0.25
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
Positive_regulation (abundant) of Gene_expression (expressed) of CCR5 associated with chemokine and chlamydia infection
5) Confidence 0.45 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.60 Pain Relevance 0.15
Tkachuk and colleagues observed that malaria infection induced the expression of CCR3 and CCR5 on placental macrophages in pregnant women [22].
Positive_regulation (induced) of Gene_expression (expression) of CCR5 in macrophages associated with malaria and infection
6) Confidence 0.41 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.61 Pain Relevance 0.20
The expression of CCR5 was found to be higher on circulating T lymphocytes from MS patients than on those from normal controls.
Positive_regulation (found) of Gene_expression (expression) of CCR5 in T lymphocytes associated with multiple sclerosis
7) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.84 Pain Relevance 0.30
The increase of CCL3 and CCL5 in the CSF during a relapse correlates with the increase in the expression of their receptor, CCR5 on TH1 lymphocytes, which results in an enhanced migratory activity of these cells towards CCL3 and CCL5.
Positive_regulation (increase) of Gene_expression (expression) of CCR5 in lymphocytes associated with recurrence
8) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.85 Pain Relevance 0.33
As shown in Fig. 4 a, Evasin-1 showed potent inhibition of ligand-induced chemotaxis of the L1.2/CCR5 transfectants.
Positive_regulation (induced) of Gene_expression (chemotaxis) of CCR5
9) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.11
As can be seen, CCR1 and CCR5 were both expressed at a higher constitutive level in the diaphragm than in the TA limb muscle under control (saline) conditions.
Positive_regulation (level) of Gene_expression (expressed) of CCR5 in limb muscle
10) Confidence 0.21 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.22 Pain Relevance 0
mRNA expression during early stages of infection at inductive sites (i.e., spleen and ILN) preceded CCR5 expression at effectors sites (i.e., fallopian tube(s), uterus, and cervix).
Positive_regulation (preceded) of in uterus Gene_expression (expression) of CCR5 in cervix associated with infection
11) Confidence 0.21 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.04 Pain Relevance 0.15

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