INT181357

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 13.09
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccl3) extracellular space (Ccl3) extracellular region (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
lung 2
macrophage 1
NK cell 1
T cells 1
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 31 99.84 Very High Very High Very High
Inflammatory mediators 16 99.62 Very High Very High Very High
antagonist 73 99.50 Very High Very High Very High
Inflammation 280 99.18 Very High Very High Very High
isoflurane 6 96.88 Very High Very High Very High
chemokine 263 95.68 Very High Very High Very High
Demyelination 12 88.52 High High
Inflammatory response 9 80.20 Quite High
cytokine 124 76.16 Quite High
Arthritis 16 75.92 Quite High
Disease Link Frequency Relevance Heat
Infection 195 99.92 Very High Very High Very High
Respiratory Syncytial Virus 421 99.76 Very High Very High Very High
INFLAMMATION 308 99.42 Very High Very High Very High
Targeted Disruption 32 99.12 Very High Very High Very High
Lymphedema 45 99.08 Very High Very High Very High
Nephritis 6 97.40 Very High Very High Very High
Disease 136 96.88 Very High Very High Very High
Pulmonary Disease 107 96.68 Very High Very High Very High
Multiple Sclerosis 79 96.52 Very High Very High Very High
Hypersensitivity 14 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL3 depletion did not alter the recruitment of natural killer (NK) cells to the lungs during the early stage, but depletion did affect the later adaptive phase.
Negative_regulation (depletion) of CCL3 in lungs
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827540 Disease Relevance 1.85 Pain Relevance 0.15
For CCL3 depletion, mice were treated with 500 ┬Ál polyclonal rabbit anti-CCL3 i.p. on days ?
Negative_regulation (depletion) of CCL3
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827540 Disease Relevance 1.02 Pain Relevance 0.22
How CCL3 depletion leads to increases in the number of pro-inflammatory CD8 cells is unclear.
Negative_regulation (depletion) of CCL3 associated with inflammation
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827540 Disease Relevance 0.78 Pain Relevance 0.12
Our finding that CCL3 inhibition enhances pathology is similar to the finding that in a model of nephritis CCR1?
Negative_regulation (inhibition) of CCL3 associated with nephritis
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827540 Disease Relevance 1.39 Pain Relevance 0.19
The effect on T cell influx in to the lung may relate to the observed reduction in CCL3 and CCL5 in lung tissue which may act at both CCR1 and CCR5 to modulate T cell recruitment in to the allergic lung [24,25].
Negative_regulation (reduction) of CCL3 in lung associated with hypersensitivity
5) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.66 Pain Relevance 0.29
We chose the L1.2/CCR5 transfectants for these analyses because we were able to test inhibition of CCL3, CCL3L1, the high-affinity variant for this receptor, and CCL4 in the same assay system.
Negative_regulation (inhibition) of CCL3
6) Confidence 0.39 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.12
While fewer T cells were recruited to the lungs of either CCL3 knockout or anti-CCL3 treated RSV infected mice, more RSV-specific pro-inflammatory T cells were recruited to the lung when CCL3 responses were impaired.
Negative_regulation (impaired) of CCL3 in T cells associated with targeted disruption, inflammation and respiratory syncytial virus
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827540 Disease Relevance 1.97 Pain Relevance 0.17
Depletion of CCL3 (by antibody or CCL3 knockout) during RSV infection reduced T cell recruitment, did not affect NK cell responses but increased recruitment of RSV-specific CD8 cells making TNF and IFN?
Negative_regulation (Depletion) of CCL3 in NK cell associated with targeted disruption, infection and respiratory syncytial virus
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827540 Disease Relevance 2.07 Pain Relevance 0.12
while other inflammatory mediators such as MCP-3 and MIP1a were inhibited by NSAID treatment in lymphedema mice.
Negative_regulation (inhibited) of MIP1a associated with inflammatory mediators, cinod and lymphedema
9) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 1.15 Pain Relevance 1.24
We chose the L1.2/CCR5 transfectants for these analyses because we were able to test inhibition of CCL3, CCL3L1, the high-affinity variant for this receptor, and CCL4 in the same assay system.
Negative_regulation (inhibition) of CCL3L1
10) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.08 Pain Relevance 0.12
CCR1 antagonist compounds were shown to inhibit CCL3 and CCL5 induced migration of MNCs in a dose dependent manner, and to reduce clinical EAE in rat [36-38].
Negative_regulation (inhibit) of CCL3 associated with multiple sclerosis and antagonist
11) Confidence 0.26 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.38 Pain Relevance 0.37
However, these drugs are unable to significantly reduce macrophage chemoattraction because they inhibit only CCL3, but not CCL4 binding to CCR5, thus probably not being of particular interest for COPD treatment.


Negative_regulation (inhibit) of CCL3 in macrophage associated with pulmonary disease
12) Confidence 0.14 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.67 Pain Relevance 0.26

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