INT181362

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 15.63
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
leukocyte 2
lymphocytes 2
ILNs 1
macrophages 1
spleen 1
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 316 99.92 Very High Very High Very High
chemokine 384 99.78 Very High Very High Very High
antagonist 63 99.50 Very High Very High Very High
Multiple sclerosis 134 97.96 Very High Very High Very High
cytokine 428 97.70 Very High Very High Very High
Central nervous system 120 90.00 High High
Demyelination 25 88.52 High High
COX2 2 80.64 Quite High
IPN 1 74.28 Quite High
Neuritis 12 74.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 319 99.92 Very High Very High Very High
Infection 324 99.72 Very High Very High Very High
Chlamydia Infection 742 99.36 Very High Very High Very High
Pneumococcal Infection 10 98.96 Very High Very High Very High
Meningitis 6 98.68 Very High Very High Very High
Bacterial Meningitis 18 98.44 Very High Very High Very High
Demyelinating Disease 157 97.96 Very High Very High Very High
Keloid Scars 11 97.84 Very High Very High Very High
Multiple Sclerosis 244 96.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 126 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antigen (Ag)-specific proliferative responses of CD4+ T cells from spleen, ILNs, and genital organs also declined after CCL5 inhibition.


Negative_regulation (inhibition) of CCL5 in spleen
1) Confidence 0.40 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2543025 Disease Relevance 0.57 Pain Relevance 0.03
It is also plausible that CCL5 blockade might reduce the ability of innate immune cells (e.g., NK cells, macrophages, etc.) to respond to C. muriduram challenge.
Negative_regulation (blockade) of CCL5 in NK cells
2) Confidence 0.40 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.56 Pain Relevance 0.12
Previously, we demonstrated that CCL5 inhibition decreased the numbers of NK1.1+ and CD11b+ leukocytes at mucosal effector sites following pneumococcal challenge [34].
Negative_regulation (inhibition) of CCL5 in leukocytes
3) Confidence 0.40 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.50 Pain Relevance 0.07
Antibody (Ab)-mediated inhibition of CCL5 during genital chlamydial infection suppressed humoral and Th1 > Th2 cellular responses by splenic-, ILN-, and genital mucosa-derived lymphocytes.
Negative_regulation (inhibition) of CCL5 in lymphocytes associated with chlamydia infection
4) Confidence 0.40 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2543025 Disease Relevance 0.62 Pain Relevance 0.04
The effect on T cell influx in to the lung may relate to the observed reduction in CCL3 and CCL5 in lung tissue which may act at both CCR1 and CCR5 to modulate T cell recruitment in to the allergic lung [24,25].
Negative_regulation (reduction) of CCL5 in lung associated with hypersensitivity
5) Confidence 0.40 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.66 Pain Relevance 0.29
Proliferative responses of C. muridarum genital infection modulated by CCL5 inhibition
Negative_regulation (inhibition) of CCL5 associated with infection
6) Confidence 0.40 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.79 Pain Relevance 0.09
32 polymorphism, the data in this study and others suggest diminished CCL5-CCR5 interactions could yield reduced fallopian tube scarring, but could also result in higher transmission/shedding of Chlamydia via decreased chlamydial clearance.
Negative_regulation (diminished) of CCL5 in fallopian tube associated with chlamydia infection and keloid scars
7) Confidence 0.40 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.13 Pain Relevance 0.09
However, T cells were the primary lymphocyte-subtype that were reduced following CCL5 blockade during the hyper cellular response to Streptococcus pneumoniae in mice.
Negative_regulation (blockade) of CCL5 in lymphocyte associated with bacterial meningitis
8) Confidence 0.35 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.53 Pain Relevance 0.07
In this study, Chlamydia infection enhanced IgG2a Ab responses, which were reduced after CCL5 inhibition.
Negative_regulation (inhibition) of CCL5 associated with chlamydia infection
9) Confidence 0.35 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.69 Pain Relevance 0.24
These findings could partially explain the inhibition of leukocyte adherence observed in B2-/- mice, as a probable consequence of decreased levels of CCL5.
Negative_regulation (decreased) of CCL5 in leukocyte
10) Confidence 0.34 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.01 Pain Relevance 0.44
While high numbers of MNCs expressing CCL2 and CCL5 were found in some patients, overall no differences were observed between MS and acute meningitis.
Negative_regulation (numbers) of CCL5 associated with multiple sclerosis and meningitis
11) Confidence 0.31 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.74 Pain Relevance 0.71
Chemokine ligand 5, Ccl5, a chemotactic signal for eosinophil and T lymphocyte recruitment into inflamed areas was also down-regulated here.
Negative_regulation (regulated) of Ccl5 in T lymphocyte associated with chemokine
12) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.90 Pain Relevance 0.59
Compelling evidence for in vivo dimer function also comes from a recent study that has shown CCL5 and CXCL4 form heterodimers, and design of peptides that disrupt this interaction inhibit atherosclerosis in hyperlipidemic mice [46].
Negative_regulation (shown) of CCL5 associated with increased venous pressure under development
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.10 Pain Relevance 0.26
We have shown that CCL5 inhibition resulted in lower IFN-?
Negative_regulation (inhibition) of CCL5
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.90 Pain Relevance 0.20
This is illustrated by its ability to suppress articular inflammation by downregulating the chemoattractive and proinflammatory molecule RANTES in RASFs on one hand [30] and to enhance destructive effects by stimulating the synthesis of IL-1 and MMP-1 on the other.
Negative_regulation (downregulating) of RANTES in articular associated with inflammation
15) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.24 Pain Relevance 0.15
CCR1 antagonist compounds were shown to inhibit CCL3 and CCL5 induced migration of MNCs in a dose dependent manner, and to reduce clinical EAE in rat [36-38].
Negative_regulation (inhibit) of CCL5 associated with multiple sclerosis and antagonist
16) Confidence 0.14 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.39 Pain Relevance 0.37
It is also plausible that CCL5 blockade might reduce the ability of innate immune cells (e.g., NK cells, macrophages, etc.) to respond to C. muriduram challenge.
Negative_regulation (blockade) of CCL5 in macrophages
17) Confidence 0.14 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.56 Pain Relevance 0.12
Antigen (Ag)-specific proliferative responses of CD4+ T cells from spleen, ILNs, and genital organs also declined after CCL5 inhibition.


Negative_regulation (inhibition) of CCL5 in ILNs
18) Confidence 0.14 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2543025 Disease Relevance 0.57 Pain Relevance 0.03
Antigen (Ag)-specific proliferative responses of CD4+ T cells from spleen, ILNs, and genital organs also declined after CCL5 inhibition.


Negative_regulation (inhibition) of CCL5 in genital organs
19) Confidence 0.14 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2543025 Disease Relevance 0.57 Pain Relevance 0.03
Chemokine ligand 5, Ccl5, a chemotactic signal for eosinophil and T lymphocyte recruitment into inflamed areas was also down-regulated here.
Negative_regulation (regulated) of Ccl5 in eosinophil associated with chemokine
20) Confidence 0.09 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2939656 Disease Relevance 0.90 Pain Relevance 0.59

General Comments

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