INT181363

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 13.65
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
leukocyte 2
brain 2
plaques 1
lung 1
T-cell 1
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 611 100.00 Very High Very High Very High
Inflammation 500 99.68 Very High Very High Very High
Demyelination 61 98.04 Very High Very High Very High
cytokine 236 97.96 Very High Very High Very High
corticosteroid 10 97.88 Very High Very High Very High
antagonist 129 97.20 Very High Very High Very High
Neuritis 30 96.28 Very High Very High Very High
Multiple sclerosis 314 94.96 High High
Neurotransmitter 8 91.28 High High
Central nervous system 269 84.60 Quite High
Disease Link Frequency Relevance Heat
Chlamydia Infection 138 99.84 Very High Very High Very High
Infection 222 99.80 Very High Very High Very High
INFLAMMATION 517 99.68 Very High Very High Very High
Multiple Sclerosis 481 99.58 Very High Very High Very High
Hepatitis 6 99.52 Very High Very High Very High
Malaria 192 99.40 Very High Very High Very High
Recurrence 81 98.96 Very High Very High Very High
Adhesions 73 98.12 Very High Very High Very High
Demyelinating Disease 391 98.04 Very High Very High Very High
Disease 155 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cDNA microarray analysis has revealed significant up-regulation of RANTES (6fold) at peak parasitaemia.
Regulation (regulation) of RANTES
1) Confidence 0.46 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.76 Pain Relevance 0.26
Up-regulation of RANTES mRNA began four days after infection, until eight days post-infectio n, approximately three-fold increase in infected mouse brain at day six and day eight post-infection compared with controls [Figure 3A].
Regulation (regulation) of RANTES in brain associated with infection
2) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.68 Pain Relevance 0.15
CCL5 modulation of Chlamydia-specific humoral responses
Regulation (modulation) of CCL5 associated with chlamydia infection
3) Confidence 0.37 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.67 Pain Relevance 0.06
Western blot analysis revealed that brain tissue transcripts of RANTES were actually translated into protein, and were significantly up-regulated (p = 0.046 for day 4 and p < 0.034 for day six and day eight post-infection) in infected mice (Figure 3A).
Regulation (regulated) of RANTES in brain associated with infection
4) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.02 Pain Relevance 0.07
Second, previous studies suggested the involvement of CCL2, CCL7, CCL8, CCL5 and CCL3 molecules in the development of plaques [39,46].
Regulation (involvement) of CCL5 in plaques
5) Confidence 0.33 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.41 Pain Relevance 0.28
From a range of chemokines measured, corrected for total protein levels, only CCL3, CCL5 and CCL11 were modulated significantly by H4R antagonism or ani-IL-13 treatment.
Regulation (modulated) of CCL5 associated with chemokine
6) Confidence 0.31 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.17 Pain Relevance 0.32
Specifically, the high up-regulation of several chemokines (CXCL2, CCL5, CXCL5, CXCL9, CXCL1 CXCL10) which control the recruitment of leukocytes to the vaccination site is important for the early phases of the immune response [45].
Regulation (regulation) of CCL5 in leukocytes associated with chemokine
7) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748717 Disease Relevance 0.25 Pain Relevance 0.18
CCL5 regulation of mucosal chlamydial immunity and infection

Background

Regulation (regulation) of CCL5 associated with infection
8) Confidence 0.25 Published 2008 Journal BMC Microbiol Section Title Doc Link PMC2543025 Disease Relevance 0.55 Pain Relevance 0.05
Marked alterations in expressio n of immunomodulator mRNA, including C-C chemokine RANTES, C-C chemokine receptors CCR1, CCR3 and CCR5, adhesion molecules PECAM-1, ICAM-1, and VCAM-1, cytokines IF N-gamma, TNF-alpha, IL-12, IL-4, and iNOS were observed to be up-regulated, while growth factors, GDF-2 and TGF-beta precursor, were down-regulated (Table 2, P < 0.05) at peak parasitaemia.


Regulation (alterations) of RANTES associated with chemokine, adhesions and cytokine
9) Confidence 0.23 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.06 Pain Relevance 0.23
The concentrations of CCL2, CCL3, CCL5, TNF?
Regulation (concentrations) of CCL5
10) Confidence 0.21 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.13 Pain Relevance 0.11
CCL2, CCL3, CCL5, CCL7, CCL8, etc...) are transcriptionally regulated during inflammation and mediate the recruitment of inflammatory cells to target tissues.
Regulation (regulated) of CCL5 associated with inflammation
11) Confidence 0.20 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.55 Pain Relevance 0.62
Conversely, anti-IL-13 treatment significantly inhibited CCL11 production, with no effect on CCL3 or CCL5.
Neg (no) Regulation (effect) of CCL5
12) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.15 Pain Relevance 0.32
RANTES – regulated upon activation normally T expressed and secreted cytokine
Regulation (regulated) of RANTES associated with cytokine
13) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.08 Pain Relevance 0.75
While the impact of anti-CCL5 immune treatment was unremarkable in the autoantigen-induced forms of EAE, antibody treatment targeting CCL5 in a mouse hepatitis virus-induced inflammatory demyelination model resulted in diminished leukocyte infiltration and reduced neurological disability [26].
Regulation (targeting) of CCL5 in leukocyte associated with multiple sclerosis, demyelination, inflammation and hepatitis
14) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.39 Pain Relevance 0.30
B, and this complex activates genes, such as rantes and il8, independent of their binding sites for NF-?
Neg (independent) Regulation (independent) of rantes
15) Confidence 0.13 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.37 Pain Relevance 0.12
Among them are macrophage inflammatory protein (MIP), MCP, CCL5 (also known as RANTES [regulated on activation, normal T-cell expressed and secreted]) and IL-8.
Regulation (regulated) of RANTES in T-cell associated with inflammation
16) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.49 Pain Relevance 0.32
With the exception of well defined changes in the CCL2, CCL3 and CCL5 levels in the CSF during relapses, most investigators observed no differences in various clinical forms of the disease [56,61,64,66].
Neg (exception) Spec (investigators) Regulation (changes) of CCL5 associated with disease and recurrence
17) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.33 Pain Relevance 0.76
Nano particles with antigen increased protein levels of interleukin (IL)-5, IL-6, and IL-13, eotaxin, macrophage chemoattractant protein (MCP)-1, and regulated on activation and normal T cells expressed and secreted (RANTES) in the lung as compared with antigen alone.
Regulation (regulated) of RANTES in lung
18) Confidence 0.04 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1242256 Disease Relevance 0.61 Pain Relevance 0.22

General Comments

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