INT181367

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.72
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 1
brain 1
Ccl21b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 94 92.16 High High
chemokine 156 85.48 High High
Central nervous system 100 82.56 Quite High
Spinal cord 16 72.12 Quite High
Multiple sclerosis 120 5.00 Very Low Very Low Very Low
Demyelination 24 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Neuritis 12 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 14 98.00 Very High Very High Very High
Bordatella Infection 4 96.08 Very High Very High Very High
INFLAMMATION 94 92.16 High High
Central Nervous System Disease 96 82.56 Quite High
Autoimmune Disease 6 79.28 Quite High
Epstein-barr Virus 4 75.64 Quite High
Multiple Sclerosis 158 73.16 Quite High
Disease 38 43.84 Quite Low
Necrosis 8 26.28 Quite Low
Cancer 8 25.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional deletion of CCR7 and CXCR3 or immune blockade of CCL19 and CCL21 reduced the binding of encephalitogenic T cells to inflamed venules in frozen brain sections.
Negative_regulation (blockade) of CCL21 in brain
1) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.82 Pain Relevance 0.47
Altogether, these data suggest that CCL19 and CCL21 are expressed in cerebral endothelial cells and are involved in ?
Negative_regulation (involved) of CCL21 in endothelial cells
2) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.91 Pain Relevance 0.51

General Comments

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