INT181368

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.48
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
venules 2
endothelial cells 1
immune system 1
Ccl21b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 312 100.00 Very High Very High Very High
Central nervous system 200 99.58 Very High Very High Very High
Inflammation 188 97.60 Very High Very High Very High
Spinal cord 32 92.60 High High
antagonist 32 62.68 Quite High
cytokine 28 58.56 Quite High
Demyelination 48 52.20 Quite High
Kinase C 4 25.44 Quite Low
Multiple sclerosis 240 7.08 Low Low
Neuritis 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Central Nervous System Disease 192 99.58 Very High Very High Very High
Disease 76 99.00 Very High Very High Very High
Epstein-barr Virus 8 98.06 Very High Very High Very High
INFLAMMATION 188 97.60 Very High Very High Very High
Hematological Disease 4 96.68 Very High Very High Very High
Adhesions 28 96.60 Very High Very High Very High
Multiple Sclerosis 316 93.64 High High
Bordatella Infection 8 89.36 High High
Recurrence 64 88.48 High High
Immunization 20 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, these data suggest that CCL19 and CCL21 are expressed in cerebral endothelial cells and are involved in ?
Gene_expression (expressed) of CCL21 in endothelial cells
1) Confidence 0.03 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.84 Pain Relevance 0.50
CCL21, CCL25, CXCL13) are constitutively expressed and control physiologic trafficking of cells of the adoptive immune system during hematopoiesis and immunosurveillance.
Gene_expression (expressed) of CCL21 in immune system associated with hematological disease
2) Confidence 0.03 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.52 Pain Relevance 0.69
Constitutive expression of the lymphoid chemokine called EBV-induced molecule 1 ligand chemokine (ELC) / CCL19 in a subpopulation of CNS venules and induced expression of the secondary lymphoid chemokine (SLC) / CCL21 in inflamed CNS venules was detected.
Gene_expression (expression) of CCL21 in venules associated with chemokine, epstein-barr virus and central nervous system
3) Confidence 0.03 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.60 Pain Relevance 0.49
In addition, CCL19 and CCL21 are expressed by endothelial cells of the BBB, and are involved in the strengthening of leukocyte adhesion to inflamed venules followed by homing of encephalitogenic T lymphocytes to the CNS.
Gene_expression (expressed) of CCL21 in venules associated with central nervous system and adhesions
4) Confidence 0.01 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.52 Pain Relevance 0.34

General Comments

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