INT181370

Context Info Confidence 0.37 First Reported 2005 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.28 Pain Relevance 0.77

Ccl19 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 84 100.00 Inflammation 86 97.00 Multiple sclerosis 60 89.52 rheumatoid arthritis 80 77.96 Central nervous system 50 77.48 cytokine 24 75.60 tolerance 9 58.80 antagonist 9 39.24 corticosteroid 3 27.84 Demyelination 12 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 91 97.00 Neurological Disease 12 96.12 Infection 4 95.04 Disease 38 92.56 Demyelinating Disease 78 89.52 Recurrence 16 88.00 Chronic Inflammatory Demyelinating Polyradiculoneuropathy 1 85.48 Encephalitis 2 85.24 Meningitis 3 84.68 Adhesions 10 81.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CXCL10, CXCL12 and CCL19 were increased in the CSF of these patients [58].

Positive_regulation (increased) of CCL19

1) Confidence 0.37 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.68 Pain Relevance 0.38

B also plays an important role in lymphoid organogenesis through the induction of the chemokines CXC12, CXCL13, CCL21 and CCL19 [44-48].

Positive_regulation (induction) of CCL19 associated with chemokine

2) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.61 Pain Relevance 0.39

General Comments

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