INT181373

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.92
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
monocytes 4
macrophage 2
leukocytes 2
neuroepithelial cells 2
T cells 2
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 192 99.84 Very High Very High Very High
Inflammation 254 99.32 Very High Very High Very High
Multiple sclerosis 135 97.00 Very High Very High Very High
Central nervous system 106 95.80 Very High Very High Very High
agonist 30 82.00 Quite High
Spinal cord 23 82.00 Quite High
imagery 9 75.36 Quite High
antagonist 38 74.08 Quite High
Neuritis 22 65.28 Quite High
Demyelination 24 62.36 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 298 100.00 Very High Very High Very High
INFLAMMATION 255 99.32 Very High Very High Very High
Recurrence 32 97.88 Very High Very High Very High
Atherosclerosis 1 97.36 Very High Very High Very High
Demyelinating Disease 167 97.00 Very High Very High Very High
Central Nervous System Disease 96 95.80 Very High Very High Very High
Acute Disease 4 92.36 High High
Pulmonary Disease 107 91.92 High High
Necrosis 10 91.60 High High
Cancer 10 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lack of CCR2RFP expression by neuroepithelial cells
Negative_regulation (Lack) of Gene_expression (expression) of CCR2RFP in neuroepithelial cells
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.21 Pain Relevance 0
Nonetheless, the ability to simultaneously image CCR2 and CX3CR1 expression in monocytes and other leukocytes represents a powerful new tool for investigating complex pathophysiology.
Negative_regulation (image) of Gene_expression (expression) of CCR2 in leukocytes
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.48 Pain Relevance 0.11
Thus, our findings reveal that Ly6Clo/CX3CR1+ monocytes are relatively excluded from the inflamed CNS of mice with EAE, regardless of CCR2 expression.
Negative_regulation (excluded) of Gene_expression (expression) of CCR2 in monocytes associated with multiple sclerosis
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.52 Pain Relevance 0.11
Thus, the authors conclude that patients with SPMS have a high expression of CCR2, a chemokine receptor associated with TH2 profile, whereas patients with RRMS preferentially display T cells with CCR5 expression and TH1 profile.
Negative_regulation (have) of Gene_expression (expression) of CCR2 in T cells associated with chemokine
4) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.93 Pain Relevance 0.17
Jee et al [15] compared the histological features and MCP-1 (CCL2) and CCR2 expression levels in the lesions of Lewis rats during the acute attack of monophasic EAE and during the first two clinical events of CR-EAE.
Negative_regulation (compared) of Gene_expression (expression) of CCR2 associated with multiple sclerosis
5) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.79 Pain Relevance 0.29
shown to reduce CCR2 expression in monocytes and their chemotaxis in response
Negative_regulation (reduce) of Gene_expression (expression) of CCR2 in monocytes
6) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 1.11 Pain Relevance 0.34
Migration of monocytes/macrophages is mainly mediated by CC chemokines including monocyte chemoattractant protein 1 (MCP-1 or CCL2), acting on its CCR2 receptor, and macrophage inflammatory proteins 1?
Negative_regulation (its) of Gene_expression (receptor) of CCR2 in macrophage associated with chemokine and inflammation
7) Confidence 0.13 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.89 Pain Relevance 0.42

General Comments

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