INT181375

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 5.54
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl22) extracellular region (Ccl22)
Anatomy Link Frequency
macrophage 2
microglia 2
neuronal 1
immune cells 1
thymus 1
Ccl22 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 221 100.00 Very High Very High Very High
cytokine 81 98.24 Very High Very High Very High
Central nervous system 100 98.08 Very High Very High Very High
Inflammation 132 97.92 Very High Very High Very High
Spinal cord 16 97.68 Very High Very High Very High
Hippocampus 2 86.44 High High
tolerance 9 15.64 Low Low
antagonist 17 13.60 Low Low
Multiple sclerosis 120 5.00 Very Low Very Low Very Low
Demyelination 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 12 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 1 100.00 Very High Very High Very High
Central Nervous System Disease 96 98.08 Very High Very High Very High
INFLAMMATION 136 97.92 Very High Very High Very High
Cancer 140 97.20 Very High Very High Very High
Motor Neuron Diseases 1 96.76 Very High Very High Very High
Multiple Sclerosis 158 95.96 Very High Very High Very High
Disease 63 95.40 Very High Very High Very High
Neurodegenerative Disease 3 94.28 High High
Rhinitis 9 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, targeting TLR2 inhibits the expression of chemokines CCL22, MCP-1 and CCR8 to attenuate the recruitment of suppressive immune cells to the tumor microenvironment [26], [35] and result in an overall reduction of suppressive cytokines in the tumor tissue.
Gene_expression (expression) of CCL22 in immune cells associated with chemokine, cancer and cytokine
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.37 Pain Relevance 0.10
This study concludes that MDC / CCL22 produced by microglia may play a role in a TH1 mediated CNS inflammation by inducing the homing of TH2 regulatory cells into the lesion site.
Gene_expression (produced) of CCL22 in microglia associated with chemokine, inflammation and central nervous system
2) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.87 Pain Relevance 0.67
Immunohistochemistry demonstrated that MDC / CCL22 is produced by infiltrating leukocytes and residential microglia, while CCR4 is expressed by infiltrating leukocytes.
Gene_expression (produced) of CCL22 in microglia associated with chemokine
3) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.82 Pain Relevance 0.70
The levels of thymus- and activation-regulated chemokine (TARC/CCL17; R&D Systems), macrophage-derived chemokine (MDC/CCL22; R&D Systems), and IL-12p40 (Endogen) in the BMDC culture supernatants and the levels of IFN-?
Gene_expression (thymus) of macrophage-derived chemokine in macrophage associated with chemokine
4) Confidence 0.09 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.24
The levels of thymus- and activation-regulated chemokine (TARC/CCL17; R&D Systems), macrophage-derived chemokine (MDC/CCL22; R&D Systems), and IL-12p40 (Endogen) in the BMDC culture supernatants and the levels of IFN-?
Gene_expression (levels) of macrophage-derived chemokine in macrophage associated with chemokine
5) Confidence 0.09 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0 Pain Relevance 0.24
DINP enhanced the expression of cell surface activation markers on BMDCs and their production of TARC/CCL17 (thymus- and activation-regulated chemokine) and MDC/CCL22 (macrophage-derived chemokine), as well as their capacity to stimulate Dp-specific T-cell proliferation.
Gene_expression (production) of macrophage-derived chemokine in thymus associated with chemokine
6) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2854722 Disease Relevance 0.68 Pain Relevance 0.22
They found that resveratrol reduced significantly the extent of neuronal cell death and neurotoxicity of the mutant proteins expressed in these two models (p25, a toxic coactivator of CDK5, and a mutant form of superoxide dismutase 1, respectively).
Gene_expression (expressed) of cell in neuronal associated with drug induced neurotoxicity and death
7) Confidence 0.02 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 1.12 Pain Relevance 0.09
The expression levels of phosphorylated c-Jun N-Terminal Kinase (pJNK) were next examined using whole cell lysate.
Gene_expression (expression) of cell lysate
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.69 Pain Relevance 0.10

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