INT181386

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 21
Disease Relevance 15.35
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
thymus 2
plasma 1
macrophage 1
Stromal cell 1
neurons 1
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 273 100.00 Very High Very High Very High
Hippocampus 315 99.56 Very High Very High Very High
antagonist 19 98.92 Very High Very High Very High
cytokine 184 96.12 Very High Very High Very High
Inflammation 100 95.72 Very High Very High Very High
Multiple sclerosis 78 89.52 High High
Central nervous system 114 79.68 Quite High
Pyramidal cell 9 78.96 Quite High
rheumatoid arthritis 1 59.40 Quite High
withdrawal 5 33.92 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 396 99.98 Very High Very High Very High
Sialadenitis 3 99.70 Very High Very High Very High
Adhesions 183 99.68 Very High Very High Very High
Necrosis 174 99.68 Very High Very High Very High
Lymphatic System Cancer 122 99.64 Very High Very High Very High
Repression 25 99.42 Very High Very High Very High
Cancer 137 98.76 Very High Very High Very High
Status Epilepticus 171 97.72 Very High Very High Very High
Injury 79 96.80 Very High Very High Very High
Neurological Disease 12 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate the role of seizures in induction of CXCL12, levels of mRNA were measured after KA-induced seizures.
Positive_regulation (induction) of CXCL12 associated with convulsion
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.62 Pain Relevance 0.08
Interestingly, Bim repression resulted in the concomitant increase in Mcl-1 and Bcl-2 levels in CXCL12-producing, but not wild-type, cells mirroring our results seen in HT29 cells (Figure 4D).
Positive_regulation (increase) of CXCL12-producing associated with repression
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.45 Pain Relevance 0
These data suggest that the upregulation of CXCL12 by seizures (Figure 4) in the adult hippocampus can increase migration of transplanted ESNPs along the septotemporal axis.
Positive_regulation (upregulation) of CXCL12 in hippocampus associated with convulsion and hippocampus
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.93 Pain Relevance 0.09
This migration is mediated by the chemokine CXCL12, which is upregulated by seizures.
Positive_regulation (upregulated) of CXCL12 associated with chemokine and convulsion
4) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 1.00 Pain Relevance 0.18
It is also of interest to examine if transient and constitutive CXCL12 stimulation of either CXCR4 or CXCR7 elicits distinct cellular outcomes.
Spec (examine) Positive_regulation (stimulation) of CXCL12
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.89 Pain Relevance 0.17
In culture, ESNPs, as well as ESC-derived immature neurons, expressed CXCR4, a receptor for CXCL12 required for CXCL12-mediated chemotaxis (Figure 3A, B).
Positive_regulation (required) of CXCL12-mediated in neurons
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.17
CXCL12 mRNA levels from whole hippocampal lysates increased approximately 3-fold within one day following KA injection and remained elevated 7 days later (Figure 4E).
Positive_regulation (increased) of CXCL12 mRNA
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.61 Pain Relevance 0.08
These results suggest an active migration process that is dependent upon CXCL12.
Positive_regulation (dependent) of CXCL12
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.11
While our data suggest that elevated levels of CXCL12 following KA-induced seizures do not alter the migration of transplanted cells, increased CXCL12 or other seizure dependent changes may affect the differentiation of transplanted cells.
Positive_regulation (increased) of CXCL12 associated with convulsion
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.91 Pain Relevance 0.04
Additionally, CXCL12 upregulation following seizures may promote a slightly more robust migratory event.
Positive_regulation (upregulation) of CXCL12 associated with convulsion
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.56 Pain Relevance 0.30
The loss of adhesion coincides with increased levels of secreted CXCL12 over that same time span, from not detectable at day 0 to a maximum after 4-days in culture (data not shown).
Positive_regulation (increased) of CXCL12 associated with adhesions
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.10 Pain Relevance 0.08
As shown in Figure 4D, immunoblot analysis showed a marked loss of Mcl-1 and Bcl-2 expression coincident with the marked increase in Bim protein levels in anoikis sensitive CXCL12- expressing cells.
Positive_regulation (increase) of CXCL12
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.52 Pain Relevance 0.04
Tonic CXCL12 stimulation induces breakdown of focal adhesions
Positive_regulation (stimulation) of CXCL12 associated with adhesions
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.13 Pain Relevance 0.09
Seizures upregulate CXCL12 and infusion of the CXCR4 antagonist AMD3100 by osmotic minipump attenuated ESNP migration.
Positive_regulation (upregulate) of CXCL12 associated with convulsion and antagonist
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013129 Disease Relevance 0.50 Pain Relevance 0.21
CXCL10, CXCL12 and CCL19 were increased in the CSF of these patients [58].
Positive_regulation (increased) of CXCL12
15) Confidence 0.22 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.68 Pain Relevance 0.38
Several studies demonstrated that in these animals the thymus exhibits enhanced deposition of extracellular matrix proteins such as fibronectin, laminin, and type IV collagen, increased chemokine contents such as CXCL12, and expression of de-adhesive molecules such as galectin-3.
Positive_regulation (increased) of CXCL12 in thymus associated with chemokine
16) Confidence 0.18 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.27 Pain Relevance 0.05
Several studies demonstrated that in these animals the thymus exhibits enhanced deposition of extracellular matrix proteins such as fibronectin, laminin, and type IV collagen, increased chemokine contents such as CXCL12, and expression of de-adhesive molecules such as galectin-3.
Positive_regulation (enhanced) of CXCL12 in thymus associated with chemokine
17) Confidence 0.18 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.27 Pain Relevance 0.05
Furthermore, the injection of the cells prevented an increase in SDF-1 (Stromal cell-Derived Factor-1) a potent B chemoattractor, which is produced by several cell types [21], thus indicating that many different immune functions can be slowed down or controlled by injection of hAFSC.
Positive_regulation (increase) of SDF-1 in Stromal cell
18) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.91 Pain Relevance 0.40
In addition, in these mice, there was an increase of levels in IL-10 and IL-1Ra and IL-6 following hAFSC injection (similar to that noted in the mice injected with hAFSC following ATN), there was no increase in SDF-1 and also they expressed lower levels of NK attractors as well as macrophage attractors.
Neg (no) Positive_regulation (increase) of SDF-1 in macrophage associated with necrosis
19) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.70 Pain Relevance 0.17
Accordingly, CXCL13 and CCL21 transcript levels were significantly increased in LESA samples while CXCL12 levels were increased in MALT lymphoma and isolated tumor cells.
Positive_regulation (increased) of CXCL12 in MALT associated with lymphatic system cancer, cancer and sialadenitis
20) Confidence 0.15 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 2.00 Pain Relevance 0.15

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