INT181395

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 13.88
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl8) extracellular region (Ccl8)
Anatomy Link Frequency
plaques 4
astrocytes 2
microglia 2
leukocyte 1
gray matter 1
Ccl8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 731 98.56 Very High Very High Very High
Multiple sclerosis 661 97.52 Very High Very High Very High
Central nervous system 552 96.84 Very High Very High Very High
cytokine 117 95.88 Very High Very High Very High
chemokine 873 95.64 Very High Very High Very High
Spinal cord 88 69.52 Quite High
Inflammatory response 19 66.84 Quite High
Neuritis 66 61.00 Quite High
antagonist 88 45.16 Quite Low
corticosteroid 22 34.88 Quite Low
Disease Link Frequency Relevance Heat
Asthma 33 100.00 Very High Very High Very High
INFLAMMATION 747 98.56 Very High Very High Very High
Multiple Sclerosis 869 98.32 Very High Very High Very High
Demyelinating Disease 864 97.52 Very High Very High Very High
Neurological Disease 133 97.48 Very High Very High Very High
Central Nervous System Disease 528 96.84 Very High Very High Very High
Encephalitis 33 95.48 Very High Very High Very High
Disorder Of Lipid Metabolism 2 95.36 Very High Very High Very High
Alzheimer's Dementia 15 94.40 High High
Pneumonia 5 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of chemoattractants Ccl5 and Ccl8, which promote monocyte and lymphocyte recruitment [106,107], is consistent with the presence of B cells and the dominance of immunoglobulin genes and the perivascular and brain parenchymal inflammatory process.
Gene_expression (Expression) of Ccl8 in B cells associated with inflammation
1) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.31 Pain Relevance 0.07
Using methods of immunohistochemistry and in situ hybridization, McManus et al [46] investigated the expression of three monocyte chemoattractant proteins, MCP-1 (CCL2), MCP-2 (CCL8) and MCP-3 (CCL7) in correlation with the temporal evolution of plaques.
Spec (investigated) Gene_expression (expression) of CCL8 in plaques
2) Confidence 0.59 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.94 Pain Relevance 0.27
In sum, the above data suggest that CCL1, CCL2, CCL3, CCL4, CCL5, CCL7 and CCL8 are expressed by residential glia and perivascular leukocytes in plaques.
Gene_expression (expressed) of CCL8 in plaques
3) Confidence 0.59 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.48 Pain Relevance 0.60
Using methods of immunohistochemistry and in situ hybridization, McManus et al [46] investigated the expression of three monocyte chemoattractant proteins, MCP-1 (CCL2), MCP-2 (CCL8) and MCP-3 (CCL7) in correlation with the temporal evolution of plaques.
Spec (investigated) Gene_expression (expression) of MCP-2 in plaques
4) Confidence 0.59 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.94 Pain Relevance 0.27
, CCL5 = RANTES, CCL7 = MCP-3, CCL8 = MCP-2] were expressed in astrocytes, microglia and other inflammatory cells within MS lesions.
Gene_expression (expressed) of MCP-2 in microglia associated with multiple sclerosis and inflammation
5) Confidence 0.59 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.10 Pain Relevance 0.45
In consensus with others, however, we also note an increased CCL7, CCL8 and CCL13 expression in the white matter as compared to the gray matter in 5 other neurological disease controls (1 viral and 1 post-infectious encephalitis, 2 Alzheimer disease and 1 Parkinson disease).
Gene_expression (expression) of CCL8 in gray matter associated with parkinson's disease, neurological disease, alzheimer's dementia and encephalitis
6) Confidence 0.59 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.79 Pain Relevance 0.24
To clarify the status of these genes, the same RNA samples that had been subjected to the microarray assay underwent qRT-PCR to determine differential expression of 14 genes previously associated with asthma by other investigators (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Pde4b, Pde4d, Slc7a2, Tgfb1), as well as 7 cytokine genes associated with asthma and/or pulmonary inflammation (Ifn?
Spec (determine) Gene_expression (expression) of Ccl8 associated with asthma, inflammation, pneumonia and cytokine
7) Confidence 0.57 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.37 Pain Relevance 0.13
We also determined that Apod and Ccl8 are expressed at very low levels in white blood cell isolates and in microdissected epithelium relative to stroma, and no differences were seen between young and old epithelium.
Gene_expression (expressed) of Ccl8 in epithelium
8) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.27 Pain Relevance 0.08
However, the fact that Ccl8 and Apod were not expressed in the peripheral leukocyte populations isolated from young and old C57BL/6 mice, suggests that these alterations are likely to be intrinsic to the smooth muscle cells and fibroblasts.


Neg (not) Gene_expression (expressed) of Ccl8 in leukocyte
9) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.78 Pain Relevance 0.34
The array of ligands for CCR2 includes MCP-1 (CCL2), MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12).
Gene_expression (includes) of CCL8
10) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.49 Pain Relevance 0.26
, CCL5 = RANTES, CCL7 = MCP-3, CCL8 = MCP-2] were expressed in astrocytes, microglia and other inflammatory cells within MS lesions.
Gene_expression (expressed) of CCL8 in microglia associated with multiple sclerosis and inflammation
11) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.10 Pain Relevance 0.45
In contrast, the expression level of CCL8 was decreased in plaques as compared to NAWM or NAGM specimens (Banisor and Kalman, unpublished observation).
Gene_expression (expression) of CCL8 in plaques
12) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.60 Pain Relevance 0.24
The array of ligands for CCR2 includes MCP-1 (CCL2), MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12).
Gene_expression (includes) of MCP-2
13) Confidence 0.51 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.49 Pain Relevance 0.26
, CCL5 = RANTES, CCL7 = MCP-3, CCL8 = MCP-2] were expressed in astrocytes, microglia and other inflammatory cells within MS lesions.
Gene_expression (expressed) of MCP-2 in astrocytes associated with multiple sclerosis and inflammation
14) Confidence 0.20 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.10 Pain Relevance 0.45
, CCL5 = RANTES, CCL7 = MCP-3, CCL8 = MCP-2] were expressed in astrocytes, microglia and other inflammatory cells within MS lesions.
Gene_expression (expressed) of CCL8 in astrocytes associated with multiple sclerosis and inflammation
15) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.10 Pain Relevance 0.45

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