INT181396

Context Info Confidence 0.48 First Reported 2005 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 6.38 Pain Relevance 2.17

extracellular space (Csf2) extracellular region (Csf2)

Anatomy Link Frequency monocytes 1 lymphocytes 1 bone marrow 1 eosinophils 1 T cells 1 Csf2 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 127 100.00 Multiple sclerosis 231 99.84 Inflammation 239 98.88 Central nervous system 106 98.36 Inflammatory stimuli 8 97.08 cytokine 297 96.40 cva 6 81.20 Inflammatory mediators 3 76.76 antagonist 9 60.12 medulla 1 44.64

Disease Link Frequency Relevance Heat Pulmonary Alveolar Proteinosis 102 100.00 Multiple Sclerosis 145 99.84 Demyelinating Disease 263 99.28 INFLAMMATION 269 98.88 Central Nervous System Disease 100 98.36 Neurological Disease 13 98.24 Meningitis 3 97.12 Colitis 62 96.64 Encephalitis 2 96.64 Chronic Inflammatory Demyelinating Polyradiculoneuropathy 1 96.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In comparison with normal controls (aortic specimens taken during ACB surgery, N = 10) overall mRNA expression of GM-CSF and its receptor subunits was distinctively elevated (N = 3) (Fig. 5).

Transcription (expression) of GM-CSF

1) Confidence 0.48 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2933604 Disease Relevance 0.15 Pain Relevance 0.07

Interestingly, G-CSF mRNA has been detected in MS lesions, and administration of recombinant G-CSF has been associated with acute MS flares in patients undergoing bone marrow transplantation (16, 17).

Transcription (detected) of CSF in bone marrow associated with multiple sclerosis

2) Confidence 0.33 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 1.10 Pain Relevance 0.32

, IL-6, KC (CXCL-1), and GM-CSF both at the protein production level and at the transcription level.

Transcription (transcription) of GM-CSF

3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.27 Pain Relevance 0.38

A similar effect was found for GM-CSF

Transcription (found) of GM-CSF

4) Confidence 0.25 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.31 Pain Relevance 0.11

effect on mRNA level of GM-CSF was less marked.

Transcription (level) of GM-CSF

5) Confidence 0.25 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233768 Disease Relevance 0.35 Pain Relevance 0.20

, IL-2, IL-3, IL-4, IL-6, IL-10,IL-17, GM-CSF, KC, and Rantes were the best discriminators of the BCG response relative to TNF-?

Transcription (discriminators) of GM-CSF associated with chemokine

6) Confidence 0.23 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.53 Pain Relevance 0.31

Accordingly, this process promotes M-CSF receptor (M-CSFR) transcription, which therefore enhances the differentiation and maturation of monocytes.

Transcription (transcription) of CSF in monocytes

7) Confidence 0.19 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.15 Pain Relevance 0

These are the first results to demonstrate familial primary PAP in humans and that GM-CSF-R?

Transcription (demonstrate) of GM-CSF associated with pulmonary alveolar proteinosis

8) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.55 Pain Relevance 0

S3 shows increased pulmonary GM-CSF levels in GM-CSF receptor ?

Transcription (levels) of GM-CSF

9) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0 Pain Relevance 0

The methods used to clone and express mRNA transcripts encoding GM-CSF-R?

Transcription (express) of GM-CSF

10) Confidence 0.12 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0 Pain Relevance 0

Giunti et al [58] detected CCR5, CCR7 and CXCR3 positive T cells in the CSF of patients with MS and other inflammatory neurological disease (IND) (meningitis, encephalitis, CIDP, neuroborreliosis).

Transcription (detected) of CSF in T cells associated with multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy, meningitis, neurological disease, inflammation and encephalitis

11) Confidence 0.11 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.40 Pain Relevance 0.46

Under these conditions, GM-CSF mRNA was stabilized and translated [12], [13].

Transcription (translated) of GM-CSF

12) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.15 Pain Relevance 0.12

We recently reported that Pin1 plays a role in the post-transcriptional control of GM-CSF mRNA expression by activated eosinophils and lymphocytes.

Transcription (expression) of GM-CSF in lymphocytes

13) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.13 Pain Relevance 0.07

independent evidences, showing that the lack of M-CSF alone was sufficient to

Neg (lack) Transcription (lack) of M-CSF

14) Confidence 0.05 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.18 Pain Relevance 0.07

We recently reported that Pin1 plays a role in the post-transcriptional control of GM-CSF mRNA expression by activated eosinophils and lymphocytes.

Transcription (expression) of GM-CSF in eosinophils

15) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1790862 Disease Relevance 0.13 Pain Relevance 0.07

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