INT181402

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.00
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
monocytes 1
lymphocytes 1
mononuclear cell 1
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 467 100.00 Very High Very High Very High
cytokine 74 99.32 Very High Very High Very High
Central nervous system 250 95.92 Very High Very High Very High
Inflammation 290 95.52 Very High Very High Very High
Demyelination 60 83.44 Quite High
antagonist 40 70.80 Quite High
Multiple sclerosis 300 65.84 Quite High
fibrosis 11 53.24 Quite High
Spinal cord 40 48.24 Quite Low
Inflammatory response 5 32.36 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 395 100.00 Very High Very High Very High
Targeted Disruption 54 98.44 Very High Very High Very High
Sepsis 26 97.76 Very High Very High Very High
Disease 105 97.36 Very High Very High Very High
Pneumovirus Infections 1 97.20 Very High Very High Very High
Demyelinating Disease 390 96.92 Very High Very High Very High
Central Nervous System Disease 240 95.92 Very High Very High Very High
INFLAMMATION 286 95.52 Very High Very High Very High
Granuloma 3 90.88 High High
Apoptosis 15 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Constitutive
                             expression levels of RANTES and MIP-1?
Negative_regulation (levels) of RANTES
1) Confidence 0.42 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.81 Pain Relevance 0.21
A more recent study [44] reveals that this distinct temporal pattern, namely the decrease in CCR1+ and increase in CCR5+ cells, may be restricted to the histological type II demyelinating lesions characterized by mononuclear cell infiltration and immunoglobulin plus complement deposition, and is not seen in type III lesions characterized by oligodendrocytopathy and apoptosis [45].
Negative_regulation (decrease) of CCR1 in mononuclear cell associated with apoptosis and demyelinating disease
2) Confidence 0.38 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.73 Pain Relevance 0.16
Finally, a recent study examined the effects of inhibiting the CC chemokine receptor, CCR1, during live-virus exposure in mice and showed that mortality during pneumovirus infection was decreased [49].
Spec (examined) Negative_regulation (inhibiting) of CCR1 associated with chemokine and pneumovirus infections
3) Confidence 0.29 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.64 Pain Relevance 0.30
Further studies demonstrated an approximately 50% reduction of clinical EAE activity in the CCR1 (-/-) mice, likely involving the altered migration of monocytes and lymphocytes [34].
Negative_regulation (reduction) of CCR1 in monocytes associated with multiple sclerosis
4) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.97 Pain Relevance 0.20
During evolution of lesions, these cells down-regulate CCR1 while retain the CCR5 expression.
Negative_regulation (regulate) of CCR1
5) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.67 Pain Relevance 0.18
In contrast to the observed EAE suppression in the CCR1 (-/-) and CCR2 (-/-) models, the CCR5 knockout mice had the same disease severity as the wild-type controls [35].
Negative_regulation (suppression) of CCR1 associated with targeted disruption, multiple sclerosis and disease
6) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.98 Pain Relevance 0.22
Further studies demonstrated an approximately 50% reduction of clinical EAE activity in the CCR1 (-/-) mice, likely involving the altered migration of monocytes and lymphocytes [34].
Negative_regulation (reduction) of CCR1 in lymphocytes associated with multiple sclerosis
7) Confidence 0.10 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.97 Pain Relevance 0.20
, RANTES, and MCP-1 was reduced in Fc?
Negative_regulation (reduced) of RANTES
8) Confidence 0.06 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.64 Pain Relevance 0.45
Interestingly, the levels of several proinflammatory cytokines such as GM-CSF, IL-6, MCP-1, and RANTES were dramatically reduced in HUVECs treated with fucoidan.
Negative_regulation (reduced) of RANTES associated with cytokine
9) Confidence 0.02 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.59 Pain Relevance 0.28

General Comments

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