INT181409

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.41
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl20) extracellular region (Ccl20)
Anatomy Link Frequency
stromal cells 2
Epithelial cell 2
Th17 cells 1
Ccl20 (Mus musculus)
Pain Link Frequency Relevance Heat
Acupuncture 21 99.98 Very High Very High Very High
Central nervous system 50 99.68 Very High Very High Very High
Spinal cord 8 96.76 Very High Very High Very High
Inflammation 148 96.08 Very High Very High Very High
Inflammatory mediators 57 94.44 High High
Crohn's disease 48 93.68 High High
Inflammatory response 45 86.56 High High
chemokine 125 83.76 Quite High
cytokine 63 80.04 Quite High
Pain 30 50.40 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 79 99.96 Very High Very High Very High
Central Nervous System Disease 48 99.68 Very High Very High Very High
Disease 82 99.04 Very High Very High Very High
Chlamydia Infection 120 98.32 Very High Very High Very High
INFLAMMATION 227 96.08 Very High Very High Very High
Sprains And Strains 14 84.68 Quite High
Inflammatory Bowel Disease 54 83.72 Quite High
Autoimmune Disease 3 81.76 Quite High
Adhesions 7 72.00 Quite High
Bordatella Infection 2 57.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The supernatants from stromal cells accumulated IL-6, CXCL1, CCL20, and PGE in a concentration dependent manner for each LPS examined (Fig. 5A–D; ANOVA, P<0.05).
Positive_regulation (accumulated) of CCL20 in stromal cells
1) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.33 Pain Relevance 0.20
The supernatants from epithelial cells also accumulated IL-6, CXCL1, and CCL20, in a concentration dependent manner for each LPS examined (Fig. 5E–G; ANOVA, P<0.05), although the epithelial cells secreted little PGE (Fig. 5H).
Positive_regulation (accumulated) of CCL20 in epithelial cells
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.30 Pain Relevance 0.18
In parallel, significant increases in CCR6 and CCL20, genes involved in the recruitment of Th17 cells, were only observed in colonic samples, supporting a less pronounced infiltration of Th17 cells in ileal inflammation.
Positive_regulation (increases) of CCL20 in Th17 cells associated with inflammation
3) Confidence 0.48 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.98 Pain Relevance 0.46
Subsequent experiments used ultrapure LPS from E. coli and focused on the accumulation of IL-6, CXCL1, CCL20, and PGE.
Positive_regulation (accumulation) of CCL20
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.26 Pain Relevance 0.11
Supernatants of the stromal cells treated with LPS accumulated IL-6, CXCL1, CCL20 and PGE over time (ANOVA, P<0.001) and in a treatment dependent manner (ANOVA, P<0.001) for each inflammatory mediator.
Positive_regulation (accumulated) of CCL20 in stromal cells associated with inflammation
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.25 Pain Relevance 0.13
Epithelial cell supernatants also accumulated more IL-6, CXCL1 and CCL20 in response to LPS over time (ANOVA, P<0.001) and in a treatment dependent manner (ANOVA, P<0.001) for each mediator.
Positive_regulation (accumulated) of CCL20 in Epithelial cell
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943929 Disease Relevance 0.24 Pain Relevance 0.12
In all stages of EAE, CCL20 and CCR6 were upregulated in the CNS.
Positive_regulation (upregulated) of CCL20 associated with multiple sclerosis and central nervous system
7) Confidence 0.33 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.01 Pain Relevance 0.52
According to the calculated RTPC for the women in this study, the expected EST after EA is unaffected by acupuncture stimulation in the ST36 and ST38 except for four of the women.
Neg (unaffected) Positive_regulation (stimulation) of ST38 associated with acupuncture
8) Confidence 0.15 Published 2010 Journal Chin Med Section Body Doc Link PMC2942886 Disease Relevance 0.05 Pain Relevance 0.10

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