INT181413

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.54
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Lck) plasma membrane (Lck) kinase activity (Lck)
cytoplasm (Lck)
Anatomy Link Frequency
macrophages 1
Lck (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 50 94.60 High High
Demyelination 12 89.64 High High
Inflammation 52 89.08 High High
chemokine 85 62.48 Quite High
Multiple sclerosis 60 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Neuritis 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 4 99.68 Very High Very High Very High
Diabetes Mellitus 154 98.64 Very High Very High Very High
Multiple Sclerosis 80 98.24 Very High Very High Very High
Central Nervous System Disease 48 94.60 High High
Demyelinating Disease 78 89.64 High High
INFLAMMATION 54 89.08 High High
Hepatitis 1 88.00 High High
Autoimmune Disease 18 81.80 Quite High
Recurrence 16 77.44 Quite High
Renal Disease 5 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The low frequency of these polymorphisms did not permit any statistical significance, suggesting that the Lck gene probably does not contribute to the genetic susceptibility to T1D [52].
Neg (not) Spec (probably) Regulation (contribute) of Lck associated with diabetes mellitus and genetic predisposition to disease
1) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.17 Pain Relevance 0
In mice with the CCL2 transgene under the control of the lck (which directs the expression of transgene to cortical thymocytes) or MBP promoters (which directs the expression of transgene to the CNS), a spontaneous infiltration of monocytes / macrophages in the thymus and CNS was observed, respectively [27].
Regulation (control) of lck in macrophages associated with central nervous system
2) Confidence 0.11 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.37 Pain Relevance 0.33

General Comments

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