INT181418

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 9.86
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) extracellular region (Ccl5) intracellular (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
brain 6
retinas 2
leukocyte 2
lung 2
cerebellum 2
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 22 99.20 Very High Very High Very High
Inflammation 273 98.28 Very High Very High Very High
corticosteroid 2 97.88 Very High Very High Very High
chemokine 312 96.56 Very High Very High Very High
Multiple sclerosis 74 93.56 High High
B1 receptor 3 92.84 High High
b2 receptor 17 91.68 High High
cytokine 80 90.32 High High
bradykinin 12 86.76 High High
Inflammatory response 30 86.08 High High
Disease Link Frequency Relevance Heat
Infection 215 99.92 Very High Very High Very High
Recurrence 17 99.24 Very High Very High Very High
Brain Hemorrhage 3 99.20 Very High Very High Very High
INFLAMMATION 298 98.28 Very High Very High Very High
Malaria 240 97.40 Very High Very High Very High
Cerebral Malaria 195 96.16 Very High Very High Very High
Disease 63 95.80 Very High Very High Very High
Demyelinating Disease 79 93.56 High High
Stress 25 92.00 High High
Injury 25 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Regulation (altered) of Gene_expression (expression) of RANTES in brain associated with malaria and infection
1) Confidence 0.52 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.78 Pain Relevance 0.20
With the exception of well defined changes in the CCL2, CCL3 and CCL5 levels in the CSF during relapses, most investigators observed no differences in various clinical forms of the disease [56,61,64,66].
Neg (exception) Regulation (changes) of Gene_expression (levels) of CCL5 associated with disease and recurrence
2) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.34 Pain Relevance 0.76
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Regulation (regulated) of Gene_expression (expression) of Ccl5 in retinas
3) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.97 Pain Relevance 0.35
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Regulation (altered) of Gene_expression (expression) of RANTES in brain associated with malaria and infection
4) Confidence 0.38 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.78 Pain Relevance 0.20
The results of RT-PCR analysis indicate that by days 6 through 8 post-infection, mRNA expression of RANTES is significantly up-regulated (p < 0.002) in infected mice compared with controls, indicating that it is involved in the immunopathogenesis in P. yoelii 17XL-infected mouse.
Regulation (regulated) of Gene_expression (expression) of RANTES associated with infection
5) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.64 Pain Relevance 0.29
Recently, the up-regulated expression of RANTES and its receptors (C CR3 and CCR5) in the cerebellar and cerebral regions of post-mortem human CM brains has been reported [8].
Regulation (regulated) of Gene_expression (expression) of RANTES in brains associated with cerebral malaria
6) Confidence 0.33 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.66 Pain Relevance 0.33
Plasmodium yoelii 17XL infection up-regulates RANTES, CCR1, CCR3 and CCR5 expression, and induces ultrastructural changes in the cerebellum

Background

Regulation (regulates) of Gene_expression (expression) of RANTES in cerebellum associated with infection
7) Confidence 0.23 Published 2005 Journal Malar J Section Title Doc Link PMC1343570 Disease Relevance 0.83 Pain Relevance 0.20
The expressed B1 is relevant to the control of CCL5 production and to ensuing leukocyte adherence and tissue inflammation.
Regulation (control) of Gene_expression (production) of CCL5 in leukocyte associated with inflammation
8) Confidence 0.21 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.13 Pain Relevance 0.49
Effects of nano particles on local expression of eotaxin, MCP-1, RANTES, and IL-6 in the presence of antigen
Regulation (Effects) of Gene_expression (expression) of RANTES
9) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.06 Pain Relevance 0.18
Effects of nano particles on local expression of eotaxin, MCP-1, RANTES, and IL-6 in the presence of antigen
Regulation (presence) of Gene_expression (expression) of RANTES
10) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.06 Pain Relevance 0.18
Nano particles with antigen increased protein levels of interleukin (IL)-5, IL-6, and IL-13, eotaxin, macrophage chemoattractant protein (MCP)-1, and regulated on activation and normal T cells expressed and secreted (RANTES) in the lung as compared with antigen alone.
Regulation (regulated) of Gene_expression (expressed) of RANTES in lung
11) Confidence 0.04 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1242256 Disease Relevance 0.61 Pain Relevance 0.22

General Comments

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