INT181422

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.76
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL15) extracellular space (CCL15) extracellular region (CCL15)
cell-cell signaling (CCL15)
Anatomy Link Frequency
macrophage 1
CCL15 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 98 100.00 Very High Very High Very High
Inflammation 87 100.00 Very High Very High Very High
cytokine 83 100.00 Very High Very High Very High
fibrosis 1 100.00 Very High Very High Very High
Demyelination 12 60.96 Quite High
Central nervous system 50 43.72 Quite Low
Inflammatory response 2 40.64 Quite Low
Multiple sclerosis 60 27.20 Quite Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
COX-2 inhibitor 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 91 100.00 Very High Very High Very High
Malignant Neoplastic Disease 4 100.00 Very High Very High Very High
Fibrosis 1 100.00 Very High Very High Very High
Infection 104 99.74 Very High Very High Very High
Herpes Simplex Virus 238 99.54 Very High Very High Very High
Demyelinating Disease 78 60.96 Quite High
Hematological Disease 1 54.96 Quite High
Sarcoma 79 50.00 Quite Low
Apoptosis 11 48.44 Quite Low
Central Nervous System Disease 48 43.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In humans, there are 27 CC chemokines, most of which including CCL2, CCL7, CCL11, CCL8, CCL13, CCL1, CCL5, CCL16, CCL14, CCL15, CCL23, CCL18, CCL3 and CCL4, respectively, are encoded as a cluster within chromosome 17q11.
Localization (including) of CCL15 associated with chemokine
1) Confidence 0.22 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.51 Pain Relevance 0.72
Compared to uninfected cells, KSHV infection induced the secretion of chemotactic cytokines (chemokines) that mediate leukocyte recruitment to sites of inflammation, fibrosis, and malignancy such as RANTES, macrophage chemoattractant protein-2 (MCP-2), MCP-3, thymus and activation-regulated chemokine (TARC), macrophage inflammatory protein (MIP-1?)
Localization (secretion) of macrophage inflammatory protein in macrophage associated with fibrosis, chemokine, malignant neoplastic disease, inflammation, herpes simplex virus, infection and cytokine
2) Confidence 0.08 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.25 Pain Relevance 0.91

General Comments

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