INT18143

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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.89
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Tbxas1) endoplasmic reticulum (Tbxas1) molecular_function (Tbxas1)
cellular_component (Tbxas1)
Anatomy Link Frequency
platelet 2
smooth muscles 1
brain 1
chest 1
epithelium 1
Tbxas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2 100.00 Very High Very High Very High
Paracetamol 3 99.36 Very High Very High Very High
Angina 18 98.84 Very High Very High Very High
ischemia 6 97.52 Very High Very High Very High
antagonist 15 96.36 Very High Very High Very High
tetrodotoxin 1 89.20 High High
qutenza 2 79.24 Quite High
cva 5 78.80 Quite High
Neurotransmitter 1 78.16 Quite High
Inflammation 11 77.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.98 Very High Very High Very High
Cv General 3 Under Development 17 98.84 Very High Very High Very High
Hepatotoxicity 2 98.48 Very High Very High Very High
Increased Venous Pressure Under Development 10 98.12 Very High Very High Very High
Cv Unclassified Under Development 4 97.52 Very High Very High Very High
Angina 4 96.56 Very High Very High Very High
Coronary Artery Disease 8 96.52 Very High Very High Very High
Coronary Heart Disease 4 96.44 Very High Very High Very High
Myocardial Infarction 4 96.16 Very High Very High Very High
Cough 8 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In repeatedly challenged animals, concentration of TxB(2) in airway lavage fluid, expression of TxS mRNA in tracheal epithelia, and the immunostaining intensity against TxS in mucous cells of the epithelium significantly increased compared with normal and sensitized animals.
Gene_expression (expression) of TxS in epithelium
1) Confidence 0.56 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11796690 Disease Relevance 0.64 Pain Relevance 0.29
Inhibitors of PLA2, cyclooxygenase and thromboxane synthetase injected i.p. 7 h after paracetamol prevented hepatotoxicity as measured by SGPT activity but did not prevent an increase in glycogen phosphorylase "a" activity.
Gene_expression (injected) of thromboxane synthetase associated with paracetamol and hepatotoxicity
2) Confidence 0.11 Published 1989 Journal Eicosanoids Section Abstract Doc Link 2516744 Disease Relevance 0.43 Pain Relevance 0.27
It mediates vasodilatory effects on pulmonary arteries and systemic circulation by relaxation of smooth muscles and prevention of platelet aggregation due to an increasing intracellular concentration of cyclic adenosin monophosphate (cAMP).5 In contrast, thromboxane6 – produced by thromboxane synthase from arachidonic acid in platelets – mediates vasoconstriction and platelet aggregation.
Gene_expression (produced) of thromboxane synthase in smooth muscles associated with increased venous pressure under development
3) Confidence 0.04 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686263 Disease Relevance 0.97 Pain Relevance 0
Some of the known compounds that modulate platelet function include: inhibitors of arachidonic acid metabolism (nonsteroidal anti-inflammatory drugs and thromboxane synthetase inhibitors), drugs that alter membrane phospholipid composition (omega 3 fatty acids), stimulators of adenylyl cyclase and guanylyl cyclase (PGE1, PGI2, PGD2/ERRF [nitric oxide], nitroglycerin, nitroprusside), phosphodiesterase inhibitors (dipyridamole and methylxanthines) and calcium antagonists (verapamil, nifedipine, diltiazem).
Gene_expression (drugs) of thromboxane synthetase in platelet associated with inflammation, antagonist and cinod
4) Confidence 0.02 Published 1994 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 8063366 Disease Relevance 0.64 Pain Relevance 0.24
We assessed the biosynthesis of thromboxane and prostacyclin as indexes of platelet activation in patients with stable and unstable coronary disease by physicochemical analysis of metabolites in plasma and urine.
Gene_expression (biosynthesis) of thromboxane in platelet associated with coronary heart disease
5) Confidence 0.01 Published 1986 Journal N. Engl. J. Med. Section Abstract Doc Link 3531859 Disease Relevance 0.77 Pain Relevance 0.37
The largest rise in thromboxane synthesis was observed in patients with unstable angina, in whom 84 percent of the episodes of chest pain were associated with phasic increases in the excretion of thromboxane and prostacyclin metabolites.
Gene_expression (synthesis) of thromboxane in chest associated with angina
6) Confidence 0.01 Published 1986 Journal N. Engl. J. Med. Section Abstract Doc Link 3531859 Disease Relevance 1.07 Pain Relevance 0.62
The concomitant application of inhibitors of thromboxane synthetase and LT synthesis was recommended for secondary prevention of thrombotic complications in patients with coronary atherosclerosis.
Gene_expression (synthesis) of thromboxane synthetase associated with coronary artery disease
7) Confidence 0.01 Published 1990 Journal Kardiologiia Section Abstract Doc Link 1965841 Disease Relevance 0.57 Pain Relevance 0.16
BN-52021 could also reduce PAF-induced production of the eicosanoid and thromboxane B in a fetal rat brain [4,71].
Gene_expression (production) of thromboxane B in brain
8) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.71 Pain Relevance 0.35
Previous studies indicate that, although significant quantities of thromboxane A2 are released from lung tissues stimulated with PAF, inhibition of thromboxane synthesis does not significantly diminish the in vitro spasmogenic response.
Gene_expression (synthesis) of thromboxane in lung
9) Confidence 0.00 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3958964 Disease Relevance 0 Pain Relevance 0.09

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