INT181434

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2005
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.06
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) extracellular space (Ccl2) signal transduction (Ccr2)
extracellular region (Ccl2) plasma membrane (Ccr2) cytoskeleton organization (Ccl2)
Anatomy Link Frequency
plaques 2
Ccr2 (Mus musculus)
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 360 99.64 Very High Very High Very High
Central nervous system 300 89.20 High High
Spinal cord 48 86.32 High High
chemokine 468 50.00 Quite Low
Inflammation 282 50.00 Quite Low
Demyelination 72 5.00 Very Low Very Low Very Low
antagonist 48 5.00 Very Low Very Low Very Low
cytokine 42 5.00 Very Low Very Low Very Low
Neuritis 36 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 468 99.64 Very High Very High Very High
Multiple Sclerosis 474 99.44 Very High Very High Very High
Apoptosis 18 92.08 High High
Central Nervous System Disease 288 89.20 High High
Immunization 30 79.04 Quite High
Targeted Disruption 60 73.72 Quite High
Stroke 6 56.96 Quite High
Progressive Multifocal Leukoencephalopathy 6 56.08 Quite High
INFLAMMATION 282 50.00 Quite Low
Disease 114 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the data from EAE and observations in MS suggest that the CCR2 – CCL2 interaction is important in the development of plaques.
CCR2 Binding (interaction) of CCL2 in plaques associated with multiple sclerosis
1) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.97 Pain Relevance 0.19
Nevertheless, the data from EAE and observations in MS suggest that the CCR2 – CCL2 interaction is important in the development of plaques.
CCR2 Binding (interaction) of CCL2 in plaques associated with multiple sclerosis
2) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.97 Pain Relevance 0.19
CCR2 is the main, but not exclusive, functional receptor for CCL2 [4], and as discussed above, the CCL2 – CCR2 interaction appears to play a key role in the development of EAE lesions.
CCR2 Binding (interaction) of CCL2 associated with multiple sclerosis
3) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.69 Pain Relevance 0.11
CCR2 is the main, but not exclusive, functional receptor for CCL2 [4], and as discussed above, the CCL2 – CCR2 interaction appears to play a key role in the development of EAE lesions.
CCR2 Binding (interaction) of CCL2 associated with multiple sclerosis
4) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.69 Pain Relevance 0.11
As CCL2 (-/-) mice did not show a compensatory upregulation of MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12) mRNA molecules, MCP-1 (CCL2) is likely to be the main ligand for CCR2 in mice with EAE.
CCR2 Spec (likely) Binding (ligand) of CCL2 associated with multiple sclerosis
5) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.37 Pain Relevance 0.22
As CCL2 (-/-) mice did not show a compensatory upregulation of MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12) mRNA molecules, MCP-1 (CCL2) is likely to be the main ligand for CCR2 in mice with EAE.
CCR2 Spec (likely) Binding (ligand) of MCP-1 associated with multiple sclerosis
6) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.37 Pain Relevance 0.22

General Comments

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