INT181435

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) DNA binding (Hand2) protein complex (Hand2)
signal transducer activity (Ccr2) cytosol (Ccr2) signal transduction (Ccr2)
Anatomy Link Frequency
T cells 2
Ccr2 (Mus musculus)
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 156 100.00 Very High Very High Very High
Multiple sclerosis 120 95.96 Very High Very High Very High
Inflammation 94 50.00 Quite Low
antagonist 16 42.16 Quite Low
Central nervous system 100 29.48 Quite Low
Demyelination 24 5.00 Very Low Very Low Very Low
Spinal cord 16 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Neuritis 12 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 32 96.84 Very High Very High Very High
Demyelinating Disease 156 95.96 Very High Very High Very High
Necrosis 8 93.60 High High
Cancer 8 93.24 High High
Disease 38 82.44 Quite High
INFLAMMATION 94 50.00 Quite Low
Central Nervous System Disease 96 29.48 Quite Low
Parkinson's Disease 2 20.68 Low Low
Alzheimer's Dementia 2 19.72 Low Low
Encephalitis 4 18.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when expressed on T cells, CCR2 is associated with the TH2 subtype as CCL2 induces differentiation of T cells into TH2 phenotype [11].
CCR2 Binding (associated) of TH2 in T cells
1) Confidence 0.17 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.89 Pain Relevance 0.15
Thus, the authors conclude that patients with SPMS have a high expression of CCR2, a chemokine receptor associated with TH2 profile, whereas patients with RRMS preferentially display T cells with CCR5 expression and TH1 profile.
CCR2 Binding (associated) of TH2 in T cells associated with chemokine
2) Confidence 0.12 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.92 Pain Relevance 0.17

General Comments

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