INT181436

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.14
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
immune cells 2
Ccl2 (Mus musculus)
Eae1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 200 100.00 Very High Very High Very High
Demyelination 48 96.48 Very High Very High Very High
Inflammation 188 95.92 Very High Very High Very High
chemokine 312 94.48 High High
Spinal cord 32 87.68 High High
cytokine 28 43.92 Quite Low
Multiple sclerosis 240 5.00 Very Low Very Low Very Low
antagonist 32 5.00 Very Low Very Low Very Low
Neuritis 24 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 316 100.00 Very High Very High Very High
Central Nervous System Disease 192 100.00 Very High Very High Very High
Demyelinating Disease 312 96.48 Very High Very High Very High
INFLAMMATION 188 95.92 Very High Very High Very High
Immunization 20 79.04 Quite High
Acute Disease 8 74.40 Quite High
Targeted Disruption 40 73.72 Quite High
Recurrence 64 51.76 Quite High
Adhesions 28 49.80 Quite Low
Disease 76 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As CCL2 (-/-) mice did not show a compensatory upregulation of MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12) mRNA molecules, MCP-1 (CCL2) is likely to be the main ligand for CCR2 in mice with EAE.
MCP-1 Spec (likely) Binding (ligand) of EAE associated with multiple sclerosis
1) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.38 Pain Relevance 0.22
As CCL2 (-/-) mice did not show a compensatory upregulation of MCP-2 (CCL8), MCP-3 (CCL7) or MCP-5 (CCL12) mRNA molecules, MCP-1 (CCL2) is likely to be the main ligand for CCR2 in mice with EAE.
CCL2 Spec (likely) Binding (ligand) of EAE associated with multiple sclerosis
2) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.37 Pain Relevance 0.22
In mice, the increased expression of MCP-1 (CCL2) by CNS immune cells is closely associated with the clinical activity of EAE [12-14].
MCP-1 Binding (associated) of EAE in immune cells associated with multiple sclerosis and central nervous system
3) Confidence 0.04 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.20 Pain Relevance 0.42
In mice, the increased expression of MCP-1 (CCL2) by CNS immune cells is closely associated with the clinical activity of EAE [12-14].
CCL2 Binding (associated) of EAE in immune cells associated with multiple sclerosis and central nervous system
4) Confidence 0.04 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.19 Pain Relevance 0.42

General Comments

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