INT181446

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2, Ccl3) extracellular region (Csf2, Ccl3) cytosol (Ccl3)
intracellular (Ccl3) cytoskeleton organization (Ccl3) kinase activity (Ccl3)
Anatomy Link Frequency
lymphocytes 1
Csf2 (Mus musculus)
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 60 97.32 Very High Very High Very High
chemokine 78 77.88 Quite High
Central nervous system 50 59.12 Quite High
cytokine 7 57.68 Quite High
Inflammation 47 50.00 Quite Low
corticosteroid 2 43.60 Quite Low
Neuritis 6 43.24 Quite Low
Demyelination 12 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Recurrence 16 99.60 Very High Very High Very High
Demyelinating Disease 78 97.32 Very High Very High Very High
Meningitis 3 74.64 Quite High
Central Nervous System Disease 48 59.12 Quite High
Multiple Sclerosis 79 54.92 Quite High
INFLAMMATION 47 50.00 Quite Low
Neurological Disease 12 43.56 Quite Low
Optic Neuritis 6 43.24 Quite Low
Syndrome 5 43.12 Quite Low
Disease 19 25.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase of CCL3 and CCL5 in the CSF during a relapse correlates with the increase in the expression of their receptor, CCR5 on TH1 lymphocytes, which results in an enhanced migratory activity of these cells towards CCL3 and CCL5.
CSF Positive_regulation (increase) of CCL3 in lymphocytes associated with recurrence
1) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.81 Pain Relevance 0.29

General Comments

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