INT18145

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Context Info
Confidence 0.66
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 18.91
Pain Relevance 9.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 12
plasma 10
sympathetic 4
endothelial cell 2
sympathetic nervous system 2
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 33 100.00 Very High Very High Very High
cytokine 14 100.00 Very High Very High Very High
adenocard 8 100.00 Very High Very High Very High
ischemia 15 99.98 Very High Very High Very High
agonist 51 99.96 Very High Very High Very High
aspirin 116 99.80 Very High Very High Very High
Angina 53 99.68 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 2 99.36 Very High Very High Very High
Spinal cord 28 98.96 Very High Very High Very High
cva 61 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 13 99.98 Very High Very High Very High
Stress 32 99.88 Very High Very High Very High
Injury 17 99.88 Very High Very High Very High
Cv General 3 Under Development 86 99.68 Very High Very High Very High
Thrombosis 30 99.40 Very High Very High Very High
Angina 27 99.36 Very High Very High Very High
Diabetes Mellitus 71 98.52 Very High Very High Very High
Myocardial Infarction 32 98.48 Very High Very High Very High
Targeted Disruption 6 98.42 Very High Very High Very High
Spasticity 5 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that limb ischemia stimulates the TXA2 production, which may be influenced not only by endothelial cell damage and the generation of oxygen free radicals but also by the activation of the sympathetic nervous system.
Positive_regulation (stimulates) of Gene_expression (production) of TXA2 in sympathetic nervous system associated with ischemia
1) Confidence 0.66 Published 1989 Journal Masui Section Abstract Doc Link 2733138 Disease Relevance 0.25 Pain Relevance 0.29
This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test.
Positive_regulation (increased) of Gene_expression (synthesis) of TxA2 in plasma
2) Confidence 0.61 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.84 Pain Relevance 0.54
These findings indicate that increased TXA2 in circulating plasma is closely correlated with the hypersensitivity of coronary arteries to EM in patients with variant angina, suggesting a possible role of augmented TXA2 production in the enhancement of coronary vascular spasticity.
Positive_regulation (augmented) of Gene_expression (production) of TXA2 in plasma associated with angina, spasticity and hypersensitivity
3) Confidence 0.52 Published 1987 Journal Jpn. Circ. J. Section Abstract Doc Link 3626009 Disease Relevance 0.96 Pain Relevance 0.40
Percutaneous transluminal coronary angioplasty is associated with transiently enhanced TXA2 biosynthesis and Aspirin-suppressable periprocedural thrombotic complications.
Positive_regulation (enhanced) of Gene_expression (biosynthesis) of TXA2 associated with aspirin and percutaneous transluminal coronary angioplasty
4) Confidence 0.50 Published 1990 Journal Stroke Section Abstract Doc Link 2260137 Disease Relevance 0.71 Pain Relevance 0.52
The increased TxA2 synthesis and the inappropriate increase of peripheral vascular response to sympathetic stimulation revert back to normal in the inactive phase.
Positive_regulation (increased) of Gene_expression (synthesis) of TxA2 in sympathetic
5) Confidence 0.50 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.72 Pain Relevance 0.46
The increased TxA2 synthesis and the inappropriate increase of peripheral vascular response to sympathetic stimulation revert back to normal in the inactive phase.
Positive_regulation (increase) of Gene_expression (synthesis) of TxA2 in sympathetic
6) Confidence 0.50 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.66 Pain Relevance 0.43
The COX-2 knockout resulted in an enhanced proliferative response to injury and in a significant increase in TXA2 biosynthesis.
Positive_regulation (increase) of Gene_expression (biosynthesis) of TXA2 associated with targeted disruption and injury
7) Confidence 0.46 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154429 Disease Relevance 0.65 Pain Relevance 0.18
This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test.
Positive_regulation (increased) of Gene_expression (synthesis) of TxA2 in plasma
8) Confidence 0.44 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.84 Pain Relevance 0.54
This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test.
Positive_regulation (elevated) of Gene_expression (synthesis) of TxA2 in plasma
9) Confidence 0.44 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.86 Pain Relevance 0.55
This exaggerated vasoconstrictor response was associated with elevated TxA2 resting levels in plasma and with increased TxA2 synthesis after the cold pressor test.
Positive_regulation (increased) of Gene_expression (synthesis) of TxA2 in plasma
10) Confidence 0.44 Published 1986 Journal Circulation Section Abstract Doc Link 3948351 Disease Relevance 0.86 Pain Relevance 0.55
Enhanced peripheral vasoconstrictor response and increased thromboxane A2 synthesis after the cold pressor test in patients with angina at rest.
Positive_regulation (increased) of Gene_expression (synthesis) of thromboxane A2 associated with cva
11) Confidence 0.41 Published 1986 Journal Circulation Section Title Doc Link 3948351 Disease Relevance 0.77 Pain Relevance 0.50
Increased thromboxane A2 generation and altered membrane fatty acid composition in platelets from patients with active angina pectoris.
Positive_regulation (Increased) of Gene_expression (generation) of thromboxane A2 in platelets associated with angina
12) Confidence 0.40 Published 1986 Journal Thromb. Res. Section Title Doc Link 3024352 Disease Relevance 0.51 Pain Relevance 0.51
The formation of the proischemic and prothrombotic thromboxane A2 (TXA2) and of its functional antagonist prostacyclin is increased in patients with unstable angina and myocardial infarction.
Positive_regulation (increased) of Gene_expression (formation) of TXA2 associated with angina, antagonist and myocardial infarction
13) Confidence 0.40 Published 1990 Journal Z Kardiol Section Abstract Doc Link 2099038 Disease Relevance 0.20 Pain Relevance 0.26
The formation of the proischemic and prothrombotic thromboxane A2 (TXA2) and of its functional antagonist prostacyclin is increased in patients with unstable angina and myocardial infarction.
Positive_regulation (increased) of Gene_expression (formation) of thromboxane A2 associated with angina, antagonist and myocardial infarction
14) Confidence 0.40 Published 1990 Journal Z Kardiol Section Abstract Doc Link 2099038 Disease Relevance 0.20 Pain Relevance 0.26
Concomitant oxidative stress also stimulates synthesis of another thromboxane receptor agonist, 8-iso prostaglandin F2?
Positive_regulation (stimulates) of Gene_expression (synthesis) of thromboxane receptor associated with stress and agonist
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.58 Pain Relevance 0.05
Diabetes is a clinical setting characterized by enhanced platelet activation that depends in part on increased platelet production of thromboxane A2.
Positive_regulation (increased) of Gene_expression (production) of thromboxane A2 in platelet associated with diabetes mellitus
16) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.54 Pain Relevance 0.22
Furthermore, exercise is associated with increased TXA2 production [29-31].
Positive_regulation (increased) of Gene_expression (production) of TXA2
17) Confidence 0.33 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2432046 Disease Relevance 0.54 Pain Relevance 0.14
The activation of synthesis of the vasoconstrictor and proaggregate TxA2 depended on the severity of clinical signs of angina pectoris.
Positive_regulation (activation) of Gene_expression (synthesis) of TxA2 associated with angina
18) Confidence 0.32 Published 1990 Journal Kardiologiia Section Abstract Doc Link 1965841 Disease Relevance 0.54 Pain Relevance 0.19
In addition, increased levels of TXA2 were observed.
Positive_regulation (increased) of Gene_expression (levels) of TXA2
19) Confidence 0.28 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.88 Pain Relevance 0.04
Diabetes is a clinical setting characterized by enhanced platelet activation that depends in part on increased platelet production of thromboxane A2.
Positive_regulation (depends) of Gene_expression (production) of thromboxane A2 in platelet associated with diabetes mellitus
20) Confidence 0.26 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.54 Pain Relevance 0.22

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