INT181450

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.19
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Ccr5, Ccl3) cytoplasm (Ccr5, Ccl3) endosome (Ccr5)
intracellular (Ccl3) signal transducer activity (Ccr5) cytosol (Ccl3)
Anatomy Link Frequency
macrophage 1
saliva 1
Ccr5 (Mus musculus)
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 157 99.52 Very High Very High Very High
antagonist 30 92.80 High High
Inflammation 119 89.44 High High
Demyelination 12 88.40 High High
Central nervous system 50 79.04 Quite High
cytokine 56 76.44 Quite High
Arthritis 9 75.40 Quite High
rheumatoid arthritis 7 67.64 Quite High
psoriasis 6 43.08 Quite Low
fibrosis 7 42.04 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 107 97.88 Very High Very High Very High
Chlamydia Infection 67 95.64 Very High Very High Very High
INFLAMMATION 121 89.44 High High
Demyelinating Disease 78 88.40 High High
Targeted Disruption 14 84.56 Quite High
Multiple Sclerosis 79 84.16 Quite High
Infection 31 81.12 Quite High
Central Nervous System Disease 48 79.04 Quite High
Arthritis 8 75.40 Quite High
Rheumatoid Arthritis 7 67.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CCL3 and CCR5 interaction promotes polarization towards the TH1 subtype.
CCR5 Binding (interaction) of CCL3
1) Confidence 0.18 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.80 Pain Relevance 0.46
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
CCR5 Binding (ligands) of CCL3 associated with chemokine and chlamydia infection
2) Confidence 0.16 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.67 Pain Relevance 0.16
As shown in Fig. 1 a, a 500-fold excess of CXCL8 had no effect on the ability of the saliva to inhibit CCL3 binding to CCR5, therefore suggesting the presence of at least two binding proteins.
CCR5 Binding (binding) of CCL3 in saliva
3) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0 Pain Relevance 0.15
However, these drugs are unable to significantly reduce macrophage chemoattraction because they inhibit only CCL3, but not CCL4 binding to CCR5, thus probably not being of particular interest for COPD treatment.


CCR5 Binding (binding) of CCL3 in macrophage associated with pulmonary disease
4) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.72 Pain Relevance 0.26

General Comments

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