INT181451

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.43
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lck, Mbp) cytoplasm (Lck, Mbp) Golgi apparatus (Lck)
nucleus (Mbp) kinase activity (Lck)
Anatomy Link Frequency
macrophages 1
Lck (Mus musculus)
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 50 97.56 Very High Very High Very High
Demyelination 12 89.64 High High
Inflammation 47 89.08 High High
chemokine 78 62.48 Quite High
Multiple sclerosis 60 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Neuritis 6 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 79 98.24 Very High Very High Very High
Central Nervous System Disease 48 97.56 Very High Very High Very High
Demyelinating Disease 78 89.64 High High
INFLAMMATION 47 89.08 High High
Hepatitis 1 88.00 High High
Recurrence 16 77.44 Quite High
Sprains And Strains 8 68.80 Quite High
Targeted Disruption 10 53.52 Quite High
Disease 19 5.00 Very Low Very Low Very Low
Neurological Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice with the CCL2 transgene under the control of the lck (which directs the expression of transgene to cortical thymocytes) or MBP promoters (which directs the expression of transgene to the CNS), a spontaneous infiltration of monocytes / macrophages in the thymus and CNS was observed, respectively [27].
lck Regulation (control) of MBP in macrophages associated with central nervous system
1) Confidence 0.08 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.43 Pain Relevance 0.34

General Comments

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