INT181455

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 12.13
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Ccr5, Ccl5) cytoplasm (Ccr5, Ccl5) endosome (Ccr5)
intracellular (Ccl5) signal transducer activity (Ccr5) signal transduction (Ccr5)
Anatomy Link Frequency
brain 2
macrophages 1
fallopian tube 1
eosinophils 1
basophils 1
Ccr5 (Mus musculus)
Ccl5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 141 99.04 Very High Very High Very High
Multiple sclerosis 60 97.36 Very High Very High Very High
Inflammatory response 36 96.76 Very High Very High Very High
antagonist 8 92.28 High High
chemokine 415 91.08 High High
cytokine 84 90.80 High High
Central nervous system 50 41.28 Quite Low
anesthesia 19 5.00 Very Low Very Low Very Low
cva 18 5.00 Very Low Very Low Very Low
Neurotransmitter 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 167 99.04 Very High Very High Very High
Keloid Scars 1 98.56 Very High Very High Very High
Demyelinating Disease 78 97.36 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 96.28 Very High Very High Very High
Chlamydia Infection 76 95.88 Very High Very High Very High
Disease 58 88.00 High High
Malaria 432 86.04 High High
Cerebral Malaria 351 85.36 High High
Infection 411 85.32 High High
Sprains And Strains 35 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in macrophages
1) Confidence 0.39 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
32 polymorphism, the data in this study and others suggest diminished CCL5-CCR5 interactions could yield reduced fallopian tube scarring, but could also result in higher transmission/shedding of Chlamydia via decreased chlamydial clearance.
CCR5 Binding (interactions) of CCL5 in fallopian tube associated with chlamydia infection and keloid scars
2) Confidence 0.36 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.13 Pain Relevance 0.09
The trafficking of inflammatory Th1 cells into the brain is mediated partly by RANTES interactions with CCR5.
CCR5 Binding (interactions) of RANTES in brain associated with inflammation
3) Confidence 0.34 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
Indeed, trafficking of inflammatory Th1 cells into the brain was reportedly mediated largely by RANTES interaction with CCR5 receptor [30].
CCR5 receptor Binding (interaction) of RANTES in brain associated with inflammation
4) Confidence 0.29 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.65 Pain Relevance 0.31
MNCs from blood constitutively expressed CCL4 and CCL5, the ligands for CCR5, in all patient groups and controls.
CCR5 Binding (ligands) of CCL5 in blood
5) Confidence 0.22 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.57 Pain Relevance 0.29
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in mast cells
6) Confidence 0.13 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in basophils
7) Confidence 0.13 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in eosinophils
8) Confidence 0.13 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in memory T-cells
9) Confidence 0.13 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in monocytes
10) Confidence 0.13 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
CCR5 Binding (binds) of RANTES in endothelial cells
11) Confidence 0.13 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.22 Pain Relevance 0.37

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