INT181463

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.67
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD63) plasma membrane (CD63)
Anatomy Link Frequency
sputum 2
basophil 2
CD63 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 100.00 Very High Very High Very High
Kinase C 34 89.84 High High
Inflammatory response 8 54.40 Quite High
Inflammation 59 50.00 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
agonist 14 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 82 100.00 Very High Very High Very High
Nicotine Addiction 111 99.50 Very High Very High Very High
Adhesions 40 88.88 High High
Brain Injury 72 36.84 Quite Low
Leukocytosis 3 12.72 Low Low
Injury 45 5.00 Very Low Very Low Very Low
Hypersensitivity 29 5.00 Very Low Very Low Very Low
Pulmonary Disease 13 5.00 Very Low Very Low Very Low
Shock 7 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In response to calcium ionophore A23187 the expression of both the activation markers CD63 and CD203c was markedly up-regulated, but quercetin exerted a significant inhibitory action, even at nanomolar doses, only on CD63, so dissecting the response of the two activation markers to the ionophore.
Regulation (regulated) of Gene_expression (expression) of CD63
1) Confidence 0.38 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.23
Figure 1 shows the dose response of the flavonoid quercetin on the expression of human basophil activation markers CD63 and CD203c following stimulation with 4 ?
Regulation (response) of Gene_expression (expression) of CD63 in basophil
2) Confidence 0.23 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0
Neither resuscitation strategy was found to influence PMN expression of CD63-positive azurophilic granules, since the surface density did not differ between patients and healthy controls at any time-point.


Regulation (influence) of Gene_expression (expression) of CD63
3) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.17 Pain Relevance 0
Smoking had also no significant effect on the levels of inflammatory mediators in sputum (additional file 1, table 3) and the expression of CD11b, CD63 and HLA-DR on CD14 high and CD14 low cells and the number of iNOS positive macrophages (data not shown).


Neg (no) Regulation (effect) of Gene_expression (expression) of CD63 in sputum associated with inflammatory mediators and nicotine addiction
4) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC554761 Disease Relevance 1.50 Pain Relevance 0.08

General Comments

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