INT18148

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.05
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1f) signal transducer activity (Htr1f)
Htr1f (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 23 100.00 Very High Very High Very High
antagonist 8 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
Sumatriptan 3 99.98 Very High Very High Very High
Dopamine 6 99.68 Very High Very High Very High
Arthritis 1 98.72 Very High Very High Very High
5HT 20 98.28 Very High Very High Very High
Opioid 1 98.08 Very High Very High Very High
antidepressant 84 93.04 High High
opioid receptor 4 92.84 High High
Disease Link Frequency Relevance Heat
Experimental Arthritis 1 98.72 Very High Very High Very High
Schizophrenia 7 98.36 Very High Very High Very High
Pressure And Volume Under Development 1 97.60 Very High Very High Very High
Anxiety Disorder 28 92.08 High High
Depression 94 88.60 High High
Suicidal Behaviour 14 84.32 Quite High
Sleep Disorders 22 82.12 Quite High
Disease 7 82.08 Quite High
Congenital Anomalies 1 68.64 Quite High
Nociception 1 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agomelatine also is a serotonin-receptor antagonist that binds to and inhibits the activity of serotonin 5HT-2C receptor subtypes, but it does not bind to other serotonin receptor subtypes. 5HT-2C receptor antagonism is associated with antidepressant and anti-anxiety activity and also increases slow-wave sleep (which is abnormally diminished in depression).35 Agomelatine does not directly affect the uptake of serotonin, norepinephrine, or dopamine.
serotonin-receptor Binding (binds) of associated with dopamine, antidepressant, depression, antagonist, anxiety disorder, 5ht and serotonin
1) Confidence 0.47 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.40 Pain Relevance 0.72
Agomelatine also is a serotonin-receptor antagonist that binds to and inhibits the activity of serotonin 5HT-2C receptor subtypes, but it does not bind to other serotonin receptor subtypes. 5HT-2C receptor antagonism is associated with antidepressant and anti-anxiety activity and also increases slow-wave sleep (which is abnormally diminished in depression).35 Agomelatine does not directly affect the uptake of serotonin, norepinephrine, or dopamine.
serotonin-receptor Binding (binds) of associated with dopamine, antidepressant, depression, antagonist, anxiety disorder, 5ht and serotonin
2) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.40 Pain Relevance 0.72
There were no significant differences in [3H]sumatriptan binding to the serotonin1D or serotonin1F receptor in Brodmann's area 9 from subjects with schizophrenia.
serotonin1F receptor Binding (binding) of associated with sumatriptan and schizophrenia
3) Confidence 0.12 Published 2006 Journal Schizophr. Res. Section Abstract Doc Link 16916599 Disease Relevance 0.77 Pain Relevance 0.30
McN-5195 did not bind to opiate, serotonin S1 or S2, dopamine D2, alpha-1, alpha-2, beta adrenergic or gamma-aminobutyric acid-A receptors and did not inhibit the synaptic uptake of norepinephrine, serotonin, dopamine or gamma-aminobutyric acid.
serotonin S1 Neg (not) Binding (bind) of associated with dopamine, opiate and serotonin
4) Confidence 0.01 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2170621 Disease Relevance 0.26 Pain Relevance 0.99
Levels of ligand binding to muscarinic cholinergic, serotonin1, beta-adrenergic and kainic acid receptors were not significantly different from control values in any of the four areas examined.
serotonin1 Binding (binding) of
5) Confidence 0.00 Published 1990 Journal Neuroscience Section Abstract Doc Link 1965859 Disease Relevance 0.21 Pain Relevance 0.49

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