INT181488

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 22
Disease Relevance 15.52
Pain Relevance 10.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Spg21) nucleus (Spg21) biological_process (Spg21)
cytoplasm (Spg21)
Anatomy Link Frequency
mast cells 12
bladder 3
bone marrow 2
sensory nerves 2
urinary bladder 1
Spg21 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 237 99.90 Very High Very High Very High
Chronic pancreatitis 165 99.76 Very High Very High Very High
Calcitonin gene-related peptide 54 99.40 Very High Very High Very High
Inflammation 723 99.34 Very High Very High Very High
Pain 171 99.08 Very High Very High Very High
Inflammatory stimuli 35 98.98 Very High Very High Very High
Inflammatory response 96 98.48 Very High Very High Very High
Inflammatory mediators 29 98.48 Very High Very High Very High
interstitial cystitis 19 96.44 Very High Very High Very High
spastic colon 27 95.00 High High
Disease Link Frequency Relevance Heat
Pancreatitis 210 99.76 Very High Very High Very High
Hypersensitivity 42 99.52 Very High Very High Very High
Pressure And Volume Under Development 39 99.36 Very High Very High Very High
INFLAMMATION 808 99.34 Very High Very High Very High
Anaphylaxis 222 98.92 Very High Very High Very High
Sprains And Strains 43 98.20 Very High Very High Very High
Neurogenic Inflammation 52 98.12 Very High Very High Very High
Rhinitis 9 97.60 Very High Very High Very High
Pain 123 96.72 Very High Very High Very High
Interstitial Cystitis 19 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cells are also increased in both acute and chronic pancreatitis [3,4] but their role in the generation of pain in pancreatitis has not been investigated.
Positive_regulation (increased) of Mast in Mast cells associated with pain, pancreatitis and chronic pancreatitis
1) Confidence 0.12 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 1.36 Pain Relevance 1.32
In both conditions, an increase in the number of mast cells has been described in the bladder and the colon, respectively [5,6].
Positive_regulation (increase) of mast in bladder
2) Confidence 0.08 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 1.18 Pain Relevance 1.15
Humans with painful chronic pancreatitis demonstrated a 3.5-fold increase in pancreatic mast cells as compared with those with painless chronic pancreatitis.
Positive_regulation (increase) of mast in mast cells associated with pain and chronic pancreatitis
3) Confidence 0.08 Published 2005 Journal BMC Gastroenterol Section Abstract Doc Link PMC554992 Disease Relevance 1.65 Pain Relevance 1.95
This positive feedback loop might be responsible for the mast cell-dependent perpetuation of bladder inflammation.
Spec (might) Positive_regulation (responsible) of mast in bladder associated with inflammation
4) Confidence 0.05 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.70 Pain Relevance 0.23
Our present findings further emphasize that products of mast cells such as tryptase inducing activation of PARs can lead to increased activity of transcription factors such as TFEB that play a fundamental role in mast cell survival.
Positive_regulation (role) of mast in mast cell
5) Confidence 0.05 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.64 Pain Relevance 0.17
We also demonstrate that deficiency in ST2 does not alter the expression of IL-33 during anaphylaxis, suggesting ST2 is regulating responses distal to the expression of IL-33 rather than acting as an autocrine enhancer of mast cell activation.
Positive_regulation (enhancer) of mast in mast cell associated with anaphylaxis
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.49 Pain Relevance 0.17
Therefore, while IL-33 may be sufficient to enhance IgE-mediated mast cell activation, we propose that IgE-mediated activation might actually reduce the capacity of that mast cell to subsequently respond to IL-33.
Positive_regulation (mediated) of mast in mast cell
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.34 Pain Relevance 0.06
This might suggest strain-specific influences on homeostatic IL-33 levels in cells such as endothelium that do not impact mast cell-derived IL-33.
Neg (not) Positive_regulation (impact) of mast in mast cell associated with sprains and strains
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.81 Pain Relevance 0.14
IgE/antigen activation of bone marrow-derived mast cells or a murine mast cell line (MC/9) significantly enhanced IL-33.
Positive_regulation (activation) of mast in bone marrow
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914748 Disease Relevance 0.74 Pain Relevance 0.32
Local activation of mast cells promotes edema, followed by the recruitment of inflammatory cells.
Positive_regulation (activation) of mast in mast cells associated with pressure and volume under development and inflammation
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914748 Disease Relevance 0.79 Pain Relevance 0.32
IgE/antigen activation of bone marrow-derived mast cells or a murine mast cell line (MC/9) significantly enhanced IL-33.
Positive_regulation (activation) of mast in bone marrow
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2914748 Disease Relevance 0.68 Pain Relevance 0.32
Kaneko et al. demonstrated that the activation of mast cells promotes late-phase anaphylactic neutrophil, but not eosinophilic, accumulation [51] in the peritoneal cavity also.
Positive_regulation (activation) of mast in peritoneal cavity associated with rhinitis and anaphylaxis
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.77 Pain Relevance 0.16
Activation of mast cells leads to the release of potent inflammatory mediators, including preformed mediators (e.g. histamine), lipid metabolites (e.g. prostaglandins) and a plethora of cytokines and chemokines [1].
Positive_regulation (Activation) of mast in mast cells associated with chemokine, inflammatory mediators and cytokine
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.40 Pain Relevance 0.21
IL-33 itself is amongst the spectrum of stimuli that can activate mast cells [15], [16], [17], [38].
Positive_regulation (activate) of mast in mast cells
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.22 Pain Relevance 0.21
After stimulation with the pro-inflammatory stimuli, the bladder of wild type mice presented signs of mast cell activation by the presence of degranulation.
Positive_regulation (activation) of mast in bladder associated with inflammatory stimuli
15) Confidence 0.02 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 0.74 Pain Relevance 0.38
Increased mast cell numbers and tryptase release represent one of the prevalent etiologic theories for interstitial cystitis and other urinary bladder inflammatory conditions.
Positive_regulation (Increased) of mast in urinary bladder associated with inflammation and interstitial cystitis
16) Confidence 0.02 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853108 Disease Relevance 0.70 Pain Relevance 0.35
Mast cells can also be primed by substance P itself because repeated doses of very low concentrations (picomolars) of substance P can induce mast cell degranulation and can lower the threshold for degranulation via subsequent cross-linking of IgE receptors by anti-IgE [96].
Positive_regulation (induce) of mast in Mast cells associated with substance p
17) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.11 Pain Relevance 0.36
More physiologic studies are needed for a better understanding of how the activation of mast cells and nerves is modulated, how sensory nerves control mast cell functions, how mast cells use sensory nerves in inducing inflammation, and the role of nerve fibres and their mediators.
Positive_regulation (activation) of mast in sensory nerves associated with inflammation
18) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.58 Pain Relevance 0.20
Subsequently, substance P and CGRP fibres have been reported to activate peptidergic mast cells in the intestinal mucosa of healthy and infected rats as well as in patients with inflammatory bowel disease [1].
Positive_regulation (activate) of mast in bowel associated with inflammation, calcitonin gene-related peptide and substance p
19) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.51 Pain Relevance 0.67
Inflammatory models have shown a significant increase in the number of mast cells, resulting in the increased release of inflammatory mediators on degranulation.
Positive_regulation (increase) of mast in mast cells associated with inflammatory mediators and inflammation
20) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.88 Pain Relevance 0.46

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