INT181489

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 10.89
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Spg21) nucleus (Spg21) biological_process (Spg21)
cytoplasm (Spg21)
Anatomy Link Frequency
mast cells 16
colon 1
Spg21 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 153 100.00 Very High Very High Very High
chemokine 9 99.76 Very High Very High Very High
substance P 286 99.70 Very High Very High Very High
Serotonin 42 99.68 Very High Very High Very High
Inflammatory response 52 99.36 Very High Very High Very High
Inflammation 655 99.34 Very High Very High Very High
cytokine 204 99.16 Very High Very High Very High
Pain 74 97.96 Very High Very High Very High
nociceptor 1 96.92 Very High Very High Very High
Calcitonin gene-related peptide 72 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 70 99.84 Very High Very High Very High
INFLAMMATION 657 99.34 Very High Very High Very High
Anaphylaxis 120 99.24 Very High Very High Very High
Nociception 15 98.82 Very High Very High Very High
Increased Venous Pressure Under Development 25 98.76 Very High Very High Very High
Pressure And Volume Under Development 22 98.12 Very High Very High Very High
Inflammatory Bowel Disease 110 98.08 Very High Very High Very High
Pain 58 97.96 Very High Very High Very High
Erythema 8 97.32 Very High Very High Very High
Microphthalmia 23 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the role for mast cells in the mediation of visceral nociceptive signaling needs to be explored further, we speculate that mast cell products released in pancreatitis, contribute to the development of pain by direct effects on nociceptors located on pancreatic afferent neurons (Figure 7).
Localization (released) of mast in mast cells associated with nociception, pain, nociceptor and pancreatitis
1) Confidence 0.12 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC554992 Disease Relevance 0.85 Pain Relevance 0.43
Several studies have shown increased numbers of mast cells or increased release of mast cell mediators from actively inflamed colon of IBD patients compared with non-inflamed colon or normal controls [13], [14], [15], [16], suggesting a potential role for mast cells in the pathogenesis of IBD.
Localization (release) of mast in colon associated with inflammatory bowel disease
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 0.85 Pain Relevance 0.17
Upon activation, mast cells can immediately release large amounts of pro-inflammatory cytokines that are contained in pre-formed granules [8] and can continue to synthesize and release a wide array of pro-inflammatory mediators de novo.
Localization (release) of mast in mast cells associated with inflammatory mediators, inflammation and cytokine
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923184 Disease Relevance 0.97 Pain Relevance 0.33
To the best of our knowledge, this is the first report describing TFEB expression in response to PAR activation in the bladder and suggest a unifying, mechanistic pathway of bladder inflammation as follows: we hypothesize that mast cells release tryptase resulting in increased PAR activation and, consequently, TFEB/MiTF activity.
Localization (release) of mast in mast cells associated with inflammation and microphthalmia
4) Confidence 0.08 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.75 Pain Relevance 0.29
However, while our data failed to detect IL-33 release from mast cells in vitro, our passive cutaneous anaphylaxis experiments demonstrates a functional role for IL-33 and ST2 during in vivo inflammation.
Localization (release) of mast in mast cells associated with inflammation and anaphylaxis
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.34 Pain Relevance 0.12
Similar cell-to-cell interactions might also be needed for mast cells to release IL-33.
Localization (release) of mast in mast cells
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.56 Pain Relevance 0.11
One possibility is that additional signals might be required for the secretion of IL-33 from mast cells.
Localization (secretion) of mast in mast cells
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.33 Pain Relevance 0.09
Mast cells can also be activated by a variety of stimuli and release distinct patterns of mediators, depending on the type and strength of stimuli [2].
Localization (release) of Mast in Mast cells
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.42 Pain Relevance 0.29
Finally, mast cells are able to release IL-1?
Localization (release) of mast in mast cells
9) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.28 Pain Relevance 0.28
Selective secretion of IL-6 from mast cells appears to be distinct from degranulation and may contribute to the development of inflammation, in which the importance of IL-6 has been recognized.
Localization (secretion) of mast in mast cells associated with inflammation
10) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.33 Pain Relevance 0.21
Furthermore, NGF has been shown to induce degranulation and histamine release from mast cells [43,44].
Localization (release) of mast in mast cells associated with nerve growth factor
11) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.23 Pain Relevance 0.75
Furthermore, Forsythe and colleagues have demonstrated that substance P and neurokinin A induce histamine release from human airway mast cells [133].
Localization (release) of mast in mast cells associated with substance p
12) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.55 Pain Relevance 0.43
In addition, substance P can cause the release of histamine [120] and TNF [121] from skin mast cells, which in turn leads to vasodilation.
Localization (release) of mast in mast cells associated with increased venous pressure under development and substance p
13) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 1.21 Pain Relevance 0.86
NGF receptors on mast cells act as autoreceptors, regulating mast cell NGF synthesis and release while at the same time being sensitive to NGF from the environment.
Localization (release) of mast in mast cell associated with nerve growth factor
14) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.30 Pain Relevance 0.74
First, Shanahan and colleagues showed that substance P caused mediator release from intestinal mucosal mast cells [135].
Localization (release) of mast in mast cells associated with substance p
15) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.49 Pain Relevance 0.67
Mast cells also secrete newly synthesized TNF within 30 minutes following certain stimuli [31].
Localization (secrete) of Mast in Mast cells
16) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.63 Pain Relevance 0.44
A study by Jiang and colleagues using an intestinal model for anaphylaxis showed that serotonin and histamine, released from the mast cells after intestinal anaphylaxis, stimulate mesenteric afferents via 5-HT3 and histamine H1 receptors [137].
Localization (released) of mast in mast cells associated with anaphylaxis and serotonin
17) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.51 Pain Relevance 0.63

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