INT181494

Context Info Confidence 0.24 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.70 Pain Relevance 1.07

endosome (NGF) signal transduction (NGF) extracellular space (NGF) extracellular region (NGF)

Anatomy Link Frequency nociceptors 2 TRPV3 (Homo sapiens) NGF (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 25 100.00 nociceptor 8 98.00 Pain 69 93.44 antagonist 2 77.88 Thermal hyperalgesia 3 75.84 Lasting pain 2 65.08 qutenza 6 61.96 Mcgill questionnaire 8 51.92 Inflammation 7 45.04 Dismenorea 3 5.00

Disease Link Frequency Relevance Heat Pain 70 93.44 Hyperalgesia 3 75.84 Macromastia 5 69.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 2 61.20 Hypersensitivity 4 51.88 Inflammatory Bowel Disease 1 45.60 INFLAMMATION 5 26.72 Dysmenorrhea 3 5.00 Infection 2 5.00 Dermatitis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It may be speculated that increased TRPV3 and TRPV4 in observed in keratinocytes may alter keratinocyte expression of NGF and other molecules, which in turn may sensitise nociceptors.

TRPV3 Spec (may) Regulation (alter) of Gene_expression (expression) of NGF in nociceptors associated with nerve growth factor and nociceptor

1) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 0.64 Pain Relevance 1.07

General Comments

This test has worked.