INT181495

Context Info Confidence 0.25 First Reported 2005 Last Reported 2007 Negated 0 Speculated 2 Reported most in Body Documents 3 Total Number 9 Disease Relevance 6.57 Pain Relevance 4.22

Anatomy Link Frequency ventral roots 2 skin 2 spinal nerve 1 peripheral nerves 1 keratinocytes 1 TRPV3 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 257 99.00 nociceptor 23 96.84 Spinal cord 77 95.36 diabetic neuropathy 56 87.04 dorsal root ganglion 224 80.16 Hyperalgesia 14 76.16 allodynia 14 75.48 qutenza 54 75.00 Nerve growth factor 92 72.48 Dismenorea 6 65.28

Disease Link Frequency Relevance Heat Injury 140 99.56 Pain 210 99.00 Diabetes Mellitus 175 98.56 Neuropathic Pain 105 95.76 Neuroma 28 94.92 Diabetic Neuropathy 56 87.04 Ganglion Cysts 231 79.20 Hyperalgesia 27 76.16 Dysmenorrhea 6 65.28 Neuritis 7 61.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TRPV3 immunoreactivity was detected most strongly in basal keratinocytes in normal skin, sometimes continuously along the length of the epidermis (Fig 8A) whilst diabetic skin showed weaker cells (Fig 8B).

Regulation (immunoreactivity) of TRPV3 in skin associated with diabetes mellitus

1) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.66 Pain Relevance 0.04

In accord, there was strong TRPV3 immunoreactivity, mostly in large calibre fibres, in ventral (Fig 6D) but not dorsal spinal roots.

Regulation (immunoreactivity) of TRPV3 in ventral

2) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.50 Pain Relevance 0.34

The weak TRPV3 immunoreactivity in dorsal roots is consistent with a preferential transport peripherally rather than centrally.

Regulation (immunoreactivity) of TRPV3 in dorsal roots

3) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.59 Pain Relevance 0.16

TRPV3 immunoreactivity was not detected in fibres in any sample.

Regulation (immunoreactivity) of TRPV3

4) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.63 Pain Relevance 0.04

The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord, Methods

Spec (investigate) Regulation (distribution) of TRPV3 in peripheral nerves associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord

5) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.94 Pain Relevance 0.59

TRPV3 immunoreactivity in the ventral roots was largely lost three to four weeks following injury.

Regulation (immunoreactivity) of TRPV3 in ventral roots associated with injury

6) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.58 Pain Relevance 0.32

TRPV3 immunoreactivity was detected in basal keratinocytes and occasional suprabasal cells throughout the epidermis.

Regulation (immunoreactivity) of TRPV3 in epidermis

7) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.05 Pain Relevance 1.05

The role of TRPV3 and TRPV4 changes in keratinocytes deserve further study.

Regulation (changes) of TRPV3 in keratinocytes

8) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Abstract Doc Link PMC554997 Disease Relevance 0.69 Pain Relevance 1.08

The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord, Methods

Spec (investigate) Regulation (distribution) of TRPV3 in spinal nerve associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord

9) Confidence 0.09 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.94 Pain Relevance 0.59

General Comments

This test has worked.