INT181495

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 6.57
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ventral roots 2
skin 2
spinal nerve 1
peripheral nerves 1
keratinocytes 1
TRPV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 257 99.00 Very High Very High Very High
nociceptor 23 96.84 Very High Very High Very High
Spinal cord 77 95.36 Very High Very High Very High
diabetic neuropathy 56 87.04 High High
dorsal root ganglion 224 80.16 Quite High
Hyperalgesia 14 76.16 Quite High
allodynia 14 75.48 Quite High
qutenza 54 75.00 Quite High
Nerve growth factor 92 72.48 Quite High
Dismenorea 6 65.28 Quite High
Disease Link Frequency Relevance Heat
Injury 140 99.56 Very High Very High Very High
Pain 210 99.00 Very High Very High Very High
Diabetes Mellitus 175 98.56 Very High Very High Very High
Neuropathic Pain 105 95.76 Very High Very High Very High
Neuroma 28 94.92 High High
Diabetic Neuropathy 56 87.04 High High
Ganglion Cysts 231 79.20 Quite High
Hyperalgesia 27 76.16 Quite High
Dysmenorrhea 6 65.28 Quite High
Neuritis 7 61.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV3 immunoreactivity was detected most strongly in basal keratinocytes in normal skin, sometimes continuously along the length of the epidermis (Fig 8A) whilst diabetic skin showed weaker cells (Fig 8B).
Regulation (immunoreactivity) of TRPV3 in skin associated with diabetes mellitus
1) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.66 Pain Relevance 0.04
In accord, there was strong TRPV3 immunoreactivity, mostly in large calibre fibres, in ventral (Fig 6D) but not dorsal spinal roots.
Regulation (immunoreactivity) of TRPV3 in ventral
2) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.50 Pain Relevance 0.34
The weak TRPV3 immunoreactivity in dorsal roots is consistent with a preferential transport peripherally rather than centrally.
Regulation (immunoreactivity) of TRPV3 in dorsal roots
3) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.59 Pain Relevance 0.16
TRPV3 immunoreactivity was not detected in fibres in any sample.
Regulation (immunoreactivity) of TRPV3
4) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.63 Pain Relevance 0.04
The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord,

Methods

Spec (investigate) Regulation (distribution) of TRPV3 in peripheral nerves associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord
5) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.94 Pain Relevance 0.59
TRPV3 immunoreactivity in the ventral roots was largely lost three to four weeks following injury.
Regulation (immunoreactivity) of TRPV3 in ventral roots associated with injury
6) Confidence 0.25 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.58 Pain Relevance 0.32
TRPV3 immunoreactivity was detected in basal keratinocytes and occasional suprabasal cells throughout the epidermis.
Regulation (immunoreactivity) of TRPV3 in epidermis
7) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.05 Pain Relevance 1.05
The role of TRPV3 and TRPV4 changes in keratinocytes deserve further study.



Regulation (changes) of TRPV3 in keratinocytes
8) Confidence 0.24 Published 2005 Journal BMC Womens Health Section Abstract Doc Link PMC554997 Disease Relevance 0.69 Pain Relevance 1.08
The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord,

Methods

Spec (investigate) Regulation (distribution) of TRPV3 in spinal nerve associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord
9) Confidence 0.09 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.94 Pain Relevance 0.59

General Comments

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