INT181496

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.32
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TRPV4) plasma membrane (TRPV4) transmembrane transport (TRPV4)
Anatomy Link Frequency
spinal nerve 1
nerve 1
peripheral nerves 1
keratinocytes 1
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 172 99.56 Very High Very High Very High
nociceptor 18 96.44 Very High Very High Very High
Spinal cord 22 93.96 High High
Nerve growth factor 62 87.04 High High
dorsal root ganglion 64 80.72 Quite High
Hyperalgesia 4 76.16 Quite High
allodynia 4 75.48 Quite High
qutenza 24 75.00 Quite High
Inflammatory mediators 4 49.12 Quite Low
Dismenorea 6 40.20 Quite Low
Disease Link Frequency Relevance Heat
Pain 160 99.56 Very High Very High Very High
Neuropathic Pain 30 96.04 Very High Very High Very High
Neuroma 8 95.20 Very High Very High Very High
Diabetes Mellitus 50 94.72 High High
Injury 40 81.68 Quite High
Ganglion Cysts 66 79.76 Quite High
Hyperalgesia 12 76.16 Quite High
INFLAMMATION 14 48.72 Quite Low
Dysmenorrhea 6 40.20 Quite Low
Amputation 6 37.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV4 immunoreactivity was also detected in fine nerve fibres scattered through the sub-epidermis, and showed a trend (p = 0.402) for increased frequency in painful subjects (Fig 4).


Regulation (immunoreactivity) of TRPV4 in nerve associated with pain
1) Confidence 0.23 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 0.75 Pain Relevance 0.97
The role of TRPV3 and TRPV4 changes in keratinocytes deserve further study.



Regulation (changes) of TRPV4 in keratinocytes
2) Confidence 0.23 Published 2005 Journal BMC Womens Health Section Abstract Doc Link PMC554997 Disease Relevance 0.68 Pain Relevance 1.07
The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord,

Methods

Spec (investigate) Regulation (distribution) of TRPV4 in peripheral nerves associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord
3) Confidence 0.22 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.94 Pain Relevance 0.59
The aim of the present study was to investigate the distribution of the vanilloid receptors TRPV1, TRPV3, TRPV4, and TRPM8 in normal and injured human peripheral nerves and spinal nerve roots and in normal and neuropathic (painful neuroma and diabetes) skin and spinal cord,

Methods

Spec (investigate) Regulation (distribution) of TRPV4 in spinal nerve associated with pain, diabetes mellitus, neuropathic pain, neuroma and spinal cord
4) Confidence 0.07 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.94 Pain Relevance 0.59

General Comments

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