INT1815

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Context Info
Confidence 0.47
First Reported 1975
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.32
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 8
kidney 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 7 100.00 Very High Very High Very High
Clonidine 11 99.98 Very High Very High Very High
Morphine 12 99.24 Very High Very High Very High
isoflurane 6 95.76 Very High Very High Very High
Potency 2 93.32 High High
Desipramine 1 88.92 High High
noradrenaline 1 85.20 High High
Serotonin 4 84.64 Quite High
withdrawal 1 82.72 Quite High
anesthesia 2 78.40 Quite High
Disease Link Frequency Relevance Heat
Hypertension 2 99.78 Very High Very High Very High
Pressure Volume 2 Under Development 1 97.80 Very High Very High Very High
Hypotension 7 97.04 Very High Very High Very High
Heart Rate Under Development 2 87.84 High High
Natriuresis 2 75.00 Quite High
Arterial-venous Cerebral Malformations 1 75.00 Quite High
Brain Hemorrhage 1 74.68 Quite High
Cv Unclassified Under Development 1 58.16 Quite High
Hypoglycemia 2 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both agents caused a marked, dose-related suppression of plasma renin activity.
Positive_regulation (caused) of Negative_regulation (suppression) of renin in plasma
1) Confidence 0.47 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 565192 Disease Relevance 0.28 Pain Relevance 0.56
These results suggest that the initial effect of fenfluramine is mediated via a serotonergic mechanism while the delayed, but long-lasting suppression of plasma renin activity, is mediated via a noradrenergic mechanism.
Positive_regulation (mediated) of Negative_regulation (suppression) of renin in plasma
2) Confidence 0.47 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.25
In various kinds of hypertension clonidine induced a decrease in urinary catecholamines, plasma renin activity and urinary aldosterone, concommitant with a fall in blood pressure and pulse rate in both short term and chronic studies.
Positive_regulation (induced) of Negative_regulation (decrease) of renin in plasma associated with pressure volume 2 under development, catecholamine, hypertension and clonidine
3) Confidence 0.46 Published 1975 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 238481 Disease Relevance 0.33 Pain Relevance 0.58
Plasma and renal renin depletion were induced by the clipping of one renal artery followed, one month later, by removal of the clipped kidney.
Positive_regulation (induced) of Negative_regulation (depletion) of renin in kidney
4) Confidence 0.40 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3913393 Disease Relevance 0 Pain Relevance 0.71
Systemic vascular resistance increased despite a 32% decrease in plasma renin activity.
Positive_regulation (increased) of Negative_regulation (decrease) of renin in plasma
5) Confidence 0.37 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1673324 Disease Relevance 0.57 Pain Relevance 0.35
Under ACTH stimulation, ANP infusion induced significant decreases in adrenal renin (from 5.0 +/- 0.08 to 2.8 +/- 0.2 ng/mg protein/h, P less than 0.05), adrenal aldosterone (from 22.7 +/- 2.3 to 16.2 +/- 1.8 ng/mg protein, P less than 0.05) and PA (from 75.5 +/- 7.4 to 61.6 +/- 4.9 ng/dl).
Positive_regulation (induced) of Negative_regulation (decreases) of renin
6) Confidence 0.35 Published 1990 Journal Endocrinol. Jpn. Section Abstract Doc Link 2166655 Disease Relevance 0.15 Pain Relevance 0.08

General Comments

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