INT181507

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 7.59
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
Notch 1
leukocytes 1
plaque 1
brain 1
cleavage 1
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 7 99.90 Very High Very High Very High
cytokine 84 98.52 Very High Very High Very High
Hippocampus 72 95.92 Very High Very High Very High
Inflammation 167 95.56 Very High Very High Very High
cINOD 151 95.28 Very High Very High Very High
Inflammatory response 33 93.72 High High
antagonist 7 82.48 Quite High
amygdala 8 78.36 Quite High
cOX1 1 76.56 Quite High
glial activation 6 73.92 Quite High
Disease Link Frequency Relevance Heat
Disease 1170 99.84 Very High Very High Very High
INFLAMMATION 237 99.70 Very High Very High Very High
Targeted Disruption 212 99.04 Very High Very High Very High
Neurodegenerative Disease 30 98.96 Very High Very High Very High
Hypoxia 18 97.96 Very High Very High Very High
Head Trauma 4 97.68 Very High Very High Very High
Brain Injury 66 96.84 Very High Very High Very High
Toxicity 15 93.84 High High
Apoptosis 43 92.52 High High
Stress 98 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Struhl and Adachi [35] systematically examined the requirements for PS1/?
Spec (examined) Positive_regulation (requirements) of PS1
1) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.13 Pain Relevance 0
PS1 has been shown to be involved in the subcellular trafficking of APP and FAD-linked PS1 variants increase the retention of substrate in compartments where ?
Positive_regulation (increase) of PS1 associated with disease
2) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.66 Pain Relevance 0.07
-secretase inhibitors markedly increase cell surface levels of PS1 and PEN-2 without affecting that of nicastrin also implies a tighter association between PS1 and PEN-2 [61].
Positive_regulation (increase) of PS1
3) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Similarly, the absence of PS1 or the expression of FAD-linked PS1 mutant results in increased glycogen synthase kinase-3?
Positive_regulation (absence) of PS1 associated with disease
4) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.64 Pain Relevance 0
De Strooper and colleagues [31] first reported a direct role for PS1 in this process when they noted loss of A?
Positive_regulation (role) of PS1
5) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.10 Pain Relevance 0
Genetic and biochemical approaches have identified three additional proteins that are crucial for the stability of PS1 as well as ?
Positive_regulation (stability) of PS1
6) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.09 Pain Relevance 0.03
Stoltenberg et al. [136] reported that lowering zinc by a 3-month dietary deficiency increased the plaque load in APPswe/PS1?
Positive_regulation (increased) of PS1 in plaque
7) Confidence 0.46 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.57 Pain Relevance 0.10
An independent C. elegans genetic screen identified aph-1 and pen-2 as enhancers of sel-12/Presenilin function, and showed that aph-2, aph-1 and pen-2 are required for Notch signaling, PS1 accumulation, and ?
Positive_regulation (accumulation) of PS1 in Notch
8) Confidence 0.46 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.06 Pain Relevance 0
Levels of PS1 and nicastrin increase significantly in activated astrocytes and microglia following brain damage by head injury, brain stabbing and inflammatory insult (Nadler et al., 2008).
Positive_regulation (increase) of PS1 in brain associated with inflammation and brain injury
9) Confidence 0.45 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.37 Pain Relevance 0.32
Beginning at 6 months of age, and coinciding with the neurodegenerative process, leukocytes and inflammatory mediators are elevated in serum of mutant PS1/PS2 conditional double knockout (PS cDKO) mice (Jiang et al., 2009).
Positive_regulation (elevated) of mutant PS1 in leukocytes associated with targeted disruption, inflammatory mediators and neurodegenerative disease
10) Confidence 0.43 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.20 Pain Relevance 0.18
These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?
Positive_regulation (manipulations) of PS1
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0
PS1 mutations are known to cause a shift in the production of A?
Positive_regulation (cause) of PS1
12) Confidence 0.35 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.49 Pain Relevance 0.19
-secretase, and/or stabilize PS1 in a certain conformation, and thus affect the site of APP cleavage by ?
Positive_regulation (stabilize) of PS1 in cleavage
13) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.35 Pain Relevance 0.09
, which increased PS1 phosphorylation [201].

8.7.

Positive_regulation (increased) of PS1
14) Confidence 0.33 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.40 Pain Relevance 0.13
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Positive_regulation (close) of PS1
15) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.03
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Positive_regulation (close) of PS1
16) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.03
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Positive_regulation (favor) of PS1
17) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.03
Next, we asked whether the G-PS1-R probe could be incorporated into the ?
Positive_regulation (incorporated) of G-PS1
18) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Positive_regulation (favor) of PS1
19) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.03
We detected a significant increase in the 598/513 ratio in the presence of fenofibrate (Figure 3A), which indicates that fenofibrate treatment induces the “closed” conformation of PS1.Conversely, ibuprofen treatment leads to a reduced 598/513 ratio (Figure 3B), inducing an “open” PS1 conformation.
Positive_regulation (inducing) of PS1
20) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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