INT181508

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
brain 2
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 52 85.00 Quite High
Inflammation 21 68.08 Quite High
imagery 10 53.92 Quite High
cINOD 6 47.56 Quite Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 19 87.80 High High
Targeted Disruption 20 86.24 High High
INFLAMMATION 28 68.08 Quite High
Disease 40 55.12 Quite High
Infection 4 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Amyloid Plaque 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Regulation (alters) of Regulation (conformation) of PS1
1) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.06 Pain Relevance 0.03
revealed a wide range of values across the TgAPPsw and PS1/APPsw mouse brain slices, with a 15.3-fold variance for A?
Regulation (range) of Regulation (values) of PS1 in brain
2) Confidence 0.31 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.45 Pain Relevance 0.17

General Comments

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