INT181509

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 11.53
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
neuronal 1
Notch 1
gonadal 1
TM1 1
brain 1
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 12 98.96 Very High Very High Very High
Inflammation 185 98.92 Very High Very High Very High
cytokine 85 91.68 High High
Glutamate 3 84.92 Quite High
imagery 70 80.68 Quite High
Hippocampus 44 78.52 Quite High
glial activation 8 77.76 Quite High
Nerve growth factor 4 77.20 Quite High
Inflammatory response 45 72.72 Quite High
Inflammatory mediators 6 72.60 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 286 99.98 Very High Very High Very High
Targeted Disruption 373 99.68 Very High Very High Very High
Aging 32 99.68 Very High Very High Very High
Disease 947 99.02 Very High Very High Very High
Hypoxia 30 99.00 Very High Very High Very High
INFLAMMATION 249 98.92 Very High Very High Very High
Dementia 53 97.92 Very High Very High Very High
Frontotemporal Dementia 40 97.12 Very High Very High Very High
Disease Progression 14 96.00 Very High Very High Very High
Parkinson's Disease 9 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, in vivo complementation of PS1 deficiency with PS2 in transgenic mice indicates functionally different roles for PS1 and PS2 [70].
Negative_regulation (deficiency) of PS1 associated with targeted disruption
1) Confidence 0.57 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.78 Pain Relevance 0
For example, deletion of TM1 through TM2 (PS1?
Negative_regulation (deletion) of PS1 in TM1
2) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
A large number of mutations in PSEN1 (?
Negative_regulation (number) of PSEN1
3) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.67 Pain Relevance 0
Similarly, PS1 expression increases in astrocytes under hypoxia conditions contributing to enhancement of intracellular calcium, whereas inhibition of PS1 reverses the effects of hypoxia on calcium signaling (Peers et al., 2004).
Negative_regulation (inhibition) of PS1 in astrocytes associated with hypoxia
4) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.67 Pain Relevance 0.19
In addition, a number of loss of function mutations in presenilin-1 have been recently associated to non-Alzheimer's dementias including frontotemporal dementia and dementia with Lewy bodies.
Negative_regulation (loss) of presenilin associated with parkinson's disease, dementia and frontotemporal dementia
5) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Abstract Doc Link PMC2887037 Disease Relevance 1.57 Pain Relevance 0.27
But interestingly, FAD-associated variant PS2N141I is able to rescue Notch-associated developmental defects compared to PS2 wt in the absence of PS1, which makes the precise functions of different PS/?
Negative_regulation (absence) of PS1 in Notch associated with disease
6) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.81 Pain Relevance 0
Similarly, TPS50, TPS90, TR50 and TR90 were unaffected by single mutation of APP or PS1 at the stimulus frequency of 0.5 Hz (data not shown).
Negative_regulation (mutation) of PS1
7) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.34 Pain Relevance 0.03
The finding that AdoMet levels in APP/PS1 mice are not decreased during aging (in contrast to wild-type mice), is probably related to less demand due to neurodegeneration.
Neg (not) Negative_regulation (decreased) of PS1 associated with aging
8) Confidence 0.35 Published 2009 Journal Neurol Sci Section Abstract Doc Link PMC2746292 Disease Relevance 0.66 Pain Relevance 0
We reasoned that dilution of the G-PS1-R probe by the wt PS1 would reduce inter-molecular FRET via competitive inhibition of the G-PS1-R/G-PS1-R dimer formation, whereas G-PS1-R intra-molecular FRET would not be affected.
Negative_regulation (inhibition) of G-PS1
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0.03
levels generally revealed significantly higher amyloid levels in the PS1/APPsw mouse brain slices compared to TgAPPsw (for soluble A?
Negative_regulation (levels) of PS1 in brain associated with alzheimer's dementia
10) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.51 Pain Relevance 0.29
These types of deficit, some of which exhibit very early onset [57, 310] have been observed in the PDAPP [53], Tg2576 [137, 329], APP23 [163, 181, 310], TgCRND8 [57], and crossed APP/PS1 [198] models.
Negative_regulation (crossed) of PS1
11) Confidence 0.26 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.60 Pain Relevance 0.10
In addition, testosterone may also reduce the protein level of PS1 [196].



Spec (may) Negative_regulation (reduce) of PS1
12) Confidence 0.22 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.33 Pain Relevance 0.03
Several potential mechanisms have been proposed: (1) estrogen may act on interlukin 6 to antagonize inflammation [193]; (2) the phenolic structure of estrogen may contribute to its antioxidant effect in cells [194]; (3) estrogen may reduce the level of appolipoprotein E (ApoE), with the isoform ApoE4 being a strong risk factor for AD development [195]; and (4) gonadal steroids may reduce the protein level of PS1 and thus ?
Negative_regulation (reduce) of PS1 in gonadal associated with inflammation and disease
13) Confidence 0.22 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.64 Pain Relevance 0.10
We recently found that APP and its derived membrane-associated form, CTFs, can regulate cell surface delivery of PS1/?
Negative_regulation (delivery) of PS1
14) Confidence 0.21 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.31 Pain Relevance 0.04
While the water maze learning was impaired in aged APPswe;PS1?
Negative_regulation (impaired) of PS1
15) Confidence 0.18 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.19 Pain Relevance 0.03
A marked and concentration-dependent impairment of pS1 and pS2 activities could be detected in the presence of ppGpp.
Negative_regulation (impairment) of pS1
16) Confidence 0.06 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0.06 Pain Relevance 0
S-dependent as it was totally impaired in the rpoS mutant, irrespective of the presence or absence of ppGpp (Fig. 9).Fig. 9Activity of the pS1 promoter in vivo and its dependence on the rpoS gene function.
Negative_regulation (impaired) of pS1 associated with addiction
17) Confidence 0.04 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0.09 Pain Relevance 0.05
Positions corresponding to pB, pS1 and pS2 transcription start sites are shown

The pS1 and pS2 promoters are negatively regulated by ppGpp and DksA in vitro

Negative_regulation (sites) of pS1
18) Confidence 0.04 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0.08 Pain Relevance 0
NAA is considered to be a good marker of neuronal viability; its decrease in APP(xPS1) mice might be caused by the intraparenchymal accumulation of A?
Negative_regulation (decrease) of xPS1 in neuronal
19) Confidence 0.01 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952791 Disease Relevance 1.23 Pain Relevance 0.20

General Comments

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