INT181521

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.99
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb8) intracellular (Hspb8) response to stress (Hspb8)
cytoplasm (Hspb8)
Anatomy Link Frequency
B lymphocytes 2
lung 2
Hspb8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 69 100.00 Very High Very High Very High
dexamethasone 27 99.30 Very High Very High Very High
cytokine 89 90.28 High High
agonist 29 82.80 Quite High
antagonist 15 74.92 Quite High
fibrosis 7 56.04 Quite High
Inflammatory response 19 41.32 Quite Low
Multiple sclerosis 5 25.44 Quite Low
Demyelination 2 12.24 Low Low
Arthritis 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 89 100.00 Very High Very High Very High
Targeted Disruption 106 99.16 Very High Very High Very High
Disease 68 97.88 Very High Very High Very High
Hypersensitivity 103 97.56 Very High Very High Very High
Asthma 100 95.60 Very High Very High Very High
Rheumatoid Arthritis 29 93.28 High High
Coronary Heart Disease 30 92.80 High High
Heart Disease 3 86.60 High High
Alzheimer's Dementia 32 79.68 Quite High
Apoptosis 10 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of HSPB8 in tTA/HSPB8 double TG (tTA/HSPB8 TG) mice was twice the NTG level, while expression of the other HSPs tested was unchanged (Figure 5A and B).
Negative_regulation (level) of Gene_expression (expression) of HSPB8 associated with targeted disruption
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.43 Pain Relevance 0.03
In parallel, levels of IL-5 and total IgE in BALF were also significantly diminished in the group treated with 2,500 ug compared to the other 2 groups (50 and 500 ug).
Negative_regulation (diminished) of Gene_expression (levels) of IgE
2) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2773769 Disease Relevance 1.09 Pain Relevance 0
Previously, some authors have shown that ATRA inhibits IgE synthesis from anti-CD40 plus IL-4 stimulated human B lymphocytes in in vitro experiments.
Negative_regulation (inhibits) of Gene_expression (synthesis) of IgE in B lymphocytes
3) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.50 Pain Relevance 0.07
Furthermore, retinoic acid inhibited CD40 plus IL-4 mediated-IgE production through alterations of sCD23, sCD54 and IL-6 production [36].
Negative_regulation (inhibited) of Gene_expression (production) of IgE
4) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.47 Pain Relevance 0.07
Vaccination with a single low dose of CpG-dinucleotide inhibited OVA-specific IgE production with subsequent upregulation of IgG2a in both groups.
Negative_regulation (inhibited) of Gene_expression (production) of IgE
5) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.31 Pain Relevance 0.11
It has been shown that systemic administration of CpG-ODN do not inhibit established IgE response while vaccination inhibits IgE production[32].
Negative_regulation (inhibits) of Gene_expression (production) of IgE
6) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.36 Pain Relevance 0.04
RAE and CsA treatments of these mice significantly inhibited the production of IgE.
Negative_regulation (inhibited) of Gene_expression (production) of IgE
7) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.25 Pain Relevance 0.12
PIO and DEX demonstrated similar abilities to reduce airway hyperresponsiveness, pulmonary recruitment of inflammatory cells, serum IgE, and lung levels of IL-4, IL-5, TNF-?
Negative_regulation (reduce) of Gene_expression (levels) of IgE in lung associated with inflammation and dexamethasone
8) Confidence 0.00 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2231357 Disease Relevance 0.57 Pain Relevance 0.45

General Comments

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