INT181523

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 7.79
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Macrophages 1
poly 1
immune cells 1
B cells 1
dendritic cells 1
Ifnar1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 178 100.00 Very High Very High Very High
Inflammation 81 100.00 Very High Very High Very High
Paracetamol 122 98.08 Very High Very High Very High
depression 4 89.96 High High
Central nervous system 29 74.36 Quite High
Parenteral administration 2 65.40 Quite High
Inflammatory response 12 63.76 Quite High
agonist 40 59.60 Quite High
addiction 1 50.20 Quite High
ischemia 18 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 90 100.00 Very High Very High Very High
Infection 630 99.60 Very High Very High Very High
Viral Infection 47 99.12 Very High Very High Very High
Disease 132 98.24 Very High Very High Very High
Systemic Lupus Erythematosus 61 96.32 Very High Very High Very High
Immunization 73 95.16 Very High Very High Very High
Coronavirus Infection 28 93.60 High High
Severe Acute Respiratory Syndrome 38 93.44 High High
Myelodysplastic Syndromes 64 90.60 High High
Depression 4 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also shown that CpG stimulate T cells by inducing APCs to synthesize IFN-I, which then act directly on T cells via IFNAR[37].
Gene_expression (synthesize) of IFN-I in T cells
1) Confidence 0.67 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.05 Pain Relevance 0.03
No differences, however, were observed in the expression of IFNAR1 or 2, STAT1, STAT2 or STAT3.
Gene_expression (expression) of IFNAR1
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.09 Pain Relevance 0.23
Regarding the role of type I IFNs in disease pathogenesis and control of viral infection, there have been several viruses for which IFNAR expression has been shown to be essential.
Gene_expression (expression) of IFNAR associated with viral infection and disease
3) Confidence 0.56 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2822618 Disease Relevance 0.52 Pain Relevance 0.03
Future work will have to focus on the similarities and differences between the neonatal and adult hosts with respect to type-I IFN triggering, signaling and responses.
Gene_expression (triggering) of type-I
4) Confidence 0.56 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242832 Disease Relevance 0.48 Pain Relevance 0.04
Viral titers in IFNAR?
Gene_expression (titers) of IFNAR
5) Confidence 0.54 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2822618 Disease Relevance 0.43 Pain Relevance 0
Type I IFN receptor expression by B cells is required for the IgG2c TI-2 antibody response
Gene_expression (expression) of IFN receptor in B cells
6) Confidence 0.49 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.32 Pain Relevance 0.06
To address whether expression of the type I IFN receptor was required by B cells for the poly(I:C)-induced IgG2c TI-2 response antibody response, Ifnar1?
Spec (whether) Gene_expression (expression) of IFN receptor in poly
7) Confidence 0.49 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.32 Pain Relevance 0.03
As mentioned before, CpG in mice results in production of several cytokines including type I IFN (IFN-?
Gene_expression (production) of I IFN associated with cytokine
8) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.72 Pain Relevance 0.20
Although these cells can be infected, they are functionally impaired: antiviral cytokines such as type I interferon were not expressed and endocytic capacity (antigen capture) was compromised ([22],[23],[24],[25],[26],[27],[28] and reviewed in [29]).
Neg (not) Gene_expression (expressed) of type I interferon associated with cytokine
9) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.51 Pain Relevance 0.13
In this regard, inflammatory monocytes, but not bone marrow-derived macrophages or dendritic cells, were recently shown to produce type 1 interferon via TLR2-MyD88 signaling in response to viral but not bacterial ligands [42].
Gene_expression (produce) of type 1 interferon in dendritic cells associated with inflammation
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.41 Pain Relevance 0.17
MDA5 recognizes MNV-1 and stimulates antigen presenting cells to produce type I interferon as well as IL-6, MCP-1, and TNF?
Gene_expression (produce) of type I interferon
11) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2443291 Disease Relevance 0.29 Pain Relevance 0.08
Furthermore, L. monocytogenes induces expression of type I interferon (IFN-??)
Gene_expression (expression) of type I interferon
12) Confidence 0.08 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.25 Pain Relevance 0
immune cells to produce more type I IFN.
Gene_expression (produce) of I IFN in immune cells
13) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.39 Pain Relevance 0.14
mice produced more type I IFN upon WNV infection.
Gene_expression (produced) of I IFN associated with infection
14) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.23 Pain Relevance 0.17
Macrophages not only produce type I IFN, proinflammatory cytokines and IL-10 upon WNV infection, but they can also be directly infected by WNV.
Gene_expression (produce) of I IFN in Macrophages associated with infection and cytokine
15) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 0.28 Pain Relevance 0.18
Activation of these TLRs results in the production of inflammatory cytokines and type I interferon.
Gene_expression (production) of type I interferon associated with inflammation and cytokine
16) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2945668 Disease Relevance 0.64 Pain Relevance 0.10
This transformation activity may depend upon co-expression of a single-chain type I cytokine receptor, such as Epo receptor, G-CSF receptor, or thrombopoietin receptor [36].
Gene_expression (expression) of type I cytokine receptor associated with cytokine
17) Confidence 0.05 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.85 Pain Relevance 0.16

General Comments

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