INT181525

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 21.51
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
lung 3
T cell 3
Eosinophils 2
lymphocytes 1
epithelium 1
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 644 100.00 Very High Very High Very High
cytokine 512 100.00 Very High Very High Very High
rheumatoid arthritis 200 99.26 Very High Very High Very High
Inflammatory response 26 99.20 Very High Very High Very High
bradykinin 15 95.56 Very High Very High Very High
agonist 46 94.28 High High
antagonist 46 91.48 High High
fibrosis 128 90.76 High High
aspirin 24 90.00 High High
Arthritis 107 89.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 623 100.00 Very High Very High Very High
Rhinitis 139 100.00 Very High Very High Very High
Lung Injury 9 100.00 Very High Very High Very High
Chronic Sinusitis 12 99.92 Very High Very High Very High
Asthma 824 99.68 Very High Very High Very High
Rheumatoid Arthritis 200 99.26 Very High Very High Very High
Stress 106 99.02 Very High Very High Very High
Hypersensitivity 242 98.88 Very High Very High Very High
Disease 254 96.08 Very High Very High Very High
Adhesions 23 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eosinophils and mast cells release IL-13, which induces IgE synthesis in cultured B cells.
Localization (release) of IL-13 in mast cells
1) Confidence 0.66 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.27 Pain Relevance 0.20
CCR1 positive T cells have been shown to be associated with IL-13 release [24] and Th2 cells are known to be the main source of IL-5 in allergic airway inflammation [27].
Localization (release) of IL-13 in T cells associated with inflammation and hypersensitivity
2) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.49 Pain Relevance 0.32
IL-13 is a unique mediator of eosinophilic inflammation, mucus hypersecretion, and AHR.19 IL-13 plays a major role in allergic inflammation by regulating the recruitment, homing, and activation of inflammatory cells.
Localization (hypersecretion) of IL-13 associated with rhinitis, inflammation and hypersensitivity
3) Confidence 0.62 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.38 Pain Relevance 0.24
Our study, however, shows that these bronchoconstrictor responses induced by oxytocin were dramatically increased by IL13.
Localization (increased) of IL13
4) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0 Pain Relevance 0.07
and IL-13 in promoting airway hyper-responsiveness inflammation and mucus hyper-secretion [23-27].
Localization (secretion) of IL-13 associated with inflammation
5) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.94 Pain Relevance 0.38
Because IL-13, but not TNF?
Localization (Because) of IL-13
6) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0 Pain Relevance 0.22
asthma, including the secretion of cytokines such as IL-4, IL-5, and IL-13,
Localization (secretion) of IL-13 associated with asthma and cytokine
7) Confidence 0.46 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.50 Pain Relevance 0.10
In Siglec-F deficient mice, similar results were observed with both IL-4 and IL-13 inducing increased Siglec-F ligand expression to a similar degree in both peribronchial cells (Figure 7E) and airway epithelium (Figure 7F), while TNF?
Localization (observed) of IL-13 in epithelium
8) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0 Pain Relevance 0.04
One possible explanation is that the increased numbers of eosinophils in the airway in Siglec-F deficient mice express increased levels of mediators that can influence mucus secretion including granule mediators (ECP, MBP)[29,30], lipid mediators (LTC4)[31], cytokines (IL-13)[31], or other at present unknown mediators.
Localization (secretion) of IL-13 in eosinophils associated with cytokine
9) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.40 Pain Relevance 0.05
In this case, the mixture of IL-13 and IFN-?
Localization (mixture) of IL-13
10) Confidence 0.36 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.80 Pain Relevance 0.34
Allergic diseases are characterized by elevated serum IgE, an inflammatory reaction with increased number of eosinophils, mast cells and an adaptative immune responses orchestrated by Th2-like CD4+ memory T cells secreting an array of cytokines such as IL-4, IL-5 and IL-13.
Localization (secreting) of IL-13 in memory T cells associated with inflammation, hypersensitivity, disease and cytokine
11) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.67 Pain Relevance 0.10
In the absence of significant numbers of infiltrating lymphocytes, the absence of IL-13 in these samples is unsurprising.
Localization (absence) of IL-13 in lymphocytes
12) Confidence 0.33 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 1.20 Pain Relevance 0.25
There was also a clear trend towards reduction of secreted IL-13 in Cerk-/- animals (- 45%; p = 0.10 vs WT), which was observed neither with Sphk1-/- nor with Sphk2-/- animals.
Localization (secreted) of IL-13
13) Confidence 0.28 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.39 Pain Relevance 0.26
, IL-2, IL-12, and IL-18 or Th2 cells that secrete IL-4, IL-5, IL-6, IL-10, and IL-13.
Localization (secrete) of IL-13 in Th2 cells
14) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721383 Disease Relevance 1.57 Pain Relevance 0.37
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Localization (levels) of IL-13 associated with rheumatoid arthritis
15) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.20 Pain Relevance 0.94
and predominance of IL-4 and IL-13, in the earliest clinically apparent RA lesions was unexpected.
Localization (predominance) of IL-13 associated with rheumatoid arthritis
16) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 1.71 Pain Relevance 0.77
Eosinophils and mast cells release IL-13, which induces IgE synthesis in cultured B cells.
Localization (release) of IL-13 in Eosinophils
17) Confidence 0.22 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.27 Pain Relevance 0.20
IL-13 is also recognized to regulate eosinophilic inflammation, and mucus secretion [29].
Localization (secretion) of IL-13 associated with rhinitis and inflammation
18) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 1.08 Pain Relevance 0.30
By secreting a plethora of typical mediators such as interleukin (IL) 4, IL-5, and IL-13, these cells hold a key position in asthma pathogenesis.
Localization (secreting) of IL-13 associated with asthma
19) Confidence 0.21 Published 2010 Journal Journal of Allergy Section Abstract Doc Link PMC2957587 Disease Relevance 0.90 Pain Relevance 0.05
Enzyme-linked immunosobent assays (ELISA) for interleukin (IL)-4 (Amersham, Buckinghamshire, UK), IL-5 (Endogen, Cambridge, MA), IL-6 (Biosource, Nivelles, Belgium), IL-13, eotaxin, macrophage chemoattractant protein (MCP)-1, and regulated on activation and normal T cells expressed and secreted (RANTES: R&D systems, Minneapolis, MN) in the lung tissue supernatants were conducted using matching antibody pairs according to the manufacture's instruction.
Localization (secreted) of IL-13 in lung
20) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox