INT18156

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 27.02
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Fap) extracellular space (Fap) plasma membrane (Fap)
Anatomy Link Frequency
fibroblasts 3
stroma 2
germline 1
epithelium 1
teeth 1
Fap (Mus musculus)
Pain Link Frequency Relevance Heat
abdominal pain 18 98.20 Very High Very High Very High
Bile 24 87.24 High High
Central nervous system 22 86.64 High High
unmyelinated 3 86.48 High High
metalloproteinase 31 84.80 Quite High
Spinal cord 4 83.08 Quite High
cINOD 26 80.24 Quite High
ischemia 1 79.04 Quite High
Sciatic nerve 1 78.64 Quite High
COX2 2 76.48 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 1598 100.00 Very High Very High Very High
Syndrome 111 100.00 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 50 100.00 Very High Very High Very High
Cancer 1895 99.92 Very High Very High Very High
Disease 268 99.92 Very High Very High Very High
Weight Loss 12 99.92 Very High Very High Very High
Targeted Disruption 20 99.80 Very High Very High Very High
Adenoma 378 99.48 Very High Very High Very High
Alzheimer's Dementia 69 98.48 Very High Very High Very High
Creutzfeldt Jakob Disease 2 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mouse model of FAP was produced by microinjecting cloned human variant TTR gene into mice.
Gene_expression (produced) of FAP associated with targeted disruption and familial amyloidotic polyneuropathy
1) Confidence 0.73 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 1966018 Disease Relevance 1.75 Pain Relevance 0.18
The FAP and FSP are not ubiquitously expressed in the stroma, but are restricted to cells that we identify as TAF and are stained in an unorganized, unparallel striated pattern.
Neg (not) Gene_expression (expressed) of FAP in stroma
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.33 Pain Relevance 0
In a murine tumor xenograft model, human tumors with admixed human MSC demonstrated cells expressing activated fibroblast-like markers including FAP, FSP, ?
Gene_expression (expressing) of FAP in fibroblast associated with cancer
3) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.32 Pain Relevance 0
Classic FAP is inherited in an autosomal dominant manner and results from a germline mutation in the adenomatous polyposis (APC) gene.
Gene_expression (inherited) of FAP in germline associated with familial adenomatous polyposis
4) Confidence 0.41 Published 2009 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2772987 Disease Relevance 3.12 Pain Relevance 0.15
APC disturbed structure and function in FAP in humans and animal models
Gene_expression (function) of FAP associated with familial adenomatous polyposis
5) Confidence 0.41 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.87 Pain Relevance 0
FAP may present with some extraintestinal manifestations such as osteomas, dental abnormalities (unerupted teeth, congenital absence of one or more teeth, supernumerary teeth, dentigerous cysts and odontomas), congenital hypertrophy of the retinal pigment epithelium (CHRPE), desmoid tumors, and extracolonic cancers (thyroid, liver, bile ducts and central nervous system).
Gene_expression (present) of FAP in teeth associated with dentigerous cyst, hypertrophy, osteoma, bile, familial adenomatous polyposis, unerupted tooth, supernumerary tooth, cancer, congenital anomalies, desmoid disease, odontoma and central nervous system
6) Confidence 0.41 Published 2009 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2772987 Disease Relevance 2.98 Pain Relevance 0.19
The FAP and FSP are not ubiquitously expressed in the stroma, but are restricted to cells that we identify as TAF and are stained in an unorganized, unparallel striated pattern.
Gene_expression (restricted) of FAP in stroma
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.34 Pain Relevance 0
FSP and FAP staining was evident within the admixed tumors that received MSC but not in the untreated controls (Figure 2A and 2B).
Gene_expression (staining) of FAP associated with cancer
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.40 Pain Relevance 0
Biglycan is elevated both in FAP patients and in FAP mice models early in disease development, before amyloid is evident.
Gene_expression (models) of FAP associated with familial amyloidotic polyneuropathy, alzheimer's dementia and disease
9) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.67 Pain Relevance 0.04
While several reports describe the use of different therapeutic strategies in mouse models for neurodegenerative disorders such as Huntington disease (HD) [6], Parkinson's disease, Alzheimer's disease (AD) [7], Prion disease [8] and other, in vivo assessment of potential therapies has not been fully exploited in FAP mouse models.
Neg (not) Gene_expression (exploited) of FAP associated with familial amyloidotic polyneuropathy, creutzfeldt jakob disease, disease, neurodegenerative disease and huntington's chorea
10) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.45 Pain Relevance 0.24
So, it would be wise to recommend a "balanced" CRC-preventive lifestyle and diet from childhood in anticipation of modulating the clinical expression of FAP.


Gene_expression (expression) of FAP associated with familial adenomatous polyposis and colon cancer
11) Confidence 0.36 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.48 Pain Relevance 0
Management of the FAP patient
Gene_expression (patient) of FAP associated with familial adenomatous polyposis
12) Confidence 0.36 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.07 Pain Relevance 0.03
MUTYH-genotype/phenotype correlations to "FAP" features
Gene_expression (features) of FAP associated with familial adenomatous polyposis
13) Confidence 0.36 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.63 Pain Relevance 0
The first characteristic requires expression of two fibroblastic markers: FAP, which is expressed on MSC and fibroblasts [40] and FSP, a marker overexpressed in TAF as compared to normal fibroblasts [41].
Gene_expression (expressed) of FAP in fibroblasts
14) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.98 Pain Relevance 0.03
The first characteristic requires expression of two fibroblastic markers: FAP, which is expressed on MSC and fibroblasts [40] and FSP, a marker overexpressed in TAF as compared to normal fibroblasts [41].
Gene_expression (expression) of FAP in fibroblasts
15) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.00 Pain Relevance 0.03
Antibodies used for western include, FAP (1?
Gene_expression (include) of FAP
16) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.18 Pain Relevance 0
Prevention and Therapy of FAP
Gene_expression (Prevention) of FAP associated with familial adenomatous polyposis
17) Confidence 0.32 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.76 Pain Relevance 0.44
An example of such a symptom is shown in Table 2, it being congenital hypertrophy of the retinal pigment epithelium (or CHRPE) that was first described in 1980 [20], which is a feature of both Gardner's syndrome and FAP.
Gene_expression (syndrome) of FAP in epithelium associated with hypertrophy, syndrome and familial adenomatous polyposis
18) Confidence 0.28 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.42 Pain Relevance 0
adenoma growth of Apcmin mice, a model of human FAP that harbors a mutation in the
Gene_expression (model) of FAP associated with adenoma
19) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.27 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox