INT181579

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Context Info
Confidence 0.71
First Reported 2005
Last Reported 2005
Negated 4
Speculated 0
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 8.59
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
kidney cortex 6
thoracic aorta 6
kidney medulla 4
plasma 1
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 323 97.44 Very High Very High Very High
anesthesia 34 65.20 Quite High
Bioavailability 17 58.72 Quite High
Inflammation 17 20.52 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 2244 99.04 Very High Very High Very High
Body Weight 119 98.16 Very High Very High Very High
Hypertrophy 85 87.60 High High
Renal Disease 136 86.24 High High
Hyperglycemia 119 78.60 Quite High
Injury 17 76.40 Quite High
Sepsis 34 74.12 Quite High
Coronary Heart Disease 17 73.56 Quite High
Coagulation Disorder 17 36.04 Quite Low
INFLAMMATION 17 20.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Phosphorylation (phosphorylation) of ET-1 in thoracic aorta associated with medulla and diabetes mellitus
1) Confidence 0.71 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.66 Pain Relevance 0.08
Determination of the plasma concentration of ET-1
Phosphorylation (concentration) of ET-1 in plasma
2) Confidence 0.70 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.10 Pain Relevance 0
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Phosphorylation (phosphorylated) of preproET-1 in kidney cortex associated with medulla
3) Confidence 0.54 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.40 Pain Relevance 0.11
We observed an up-regulation of inducible nitric oxide synthase (iNOS), prepro endothelin-1 (preproET-1) and phosphorylated p38-MAPK in thoracic aorta and kidney cortex but not in kidney medulla in 28-days diabetes group.


Neg (not) Phosphorylation (phosphorylated) of endothelin-1 in thoracic aorta associated with medulla and diabetes mellitus
4) Confidence 0.54 Published 2005 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC555576 Disease Relevance 1.03 Pain Relevance 0.09
We observed an up-regulation of inducible nitric oxide synthase (iNOS), prepro endothelin-1 (preproET-1) and phosphorylated p38-MAPK in thoracic aorta and kidney cortex but not in kidney medulla in 28-days diabetes group.


Neg (not) Phosphorylation (phosphorylated) of preproET-1 in thoracic aorta associated with medulla and diabetes mellitus
5) Confidence 0.54 Published 2005 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC555576 Disease Relevance 1.02 Pain Relevance 0.09
PreproET-1, iNOS, eNOS, total and phosphorylated p38-MAPK and ERK protein expressions of thoracic aorta, kidney cortex and kidney medulla were determined using standard SDS-PAGE and immunoblot technique.
Phosphorylation (phosphorylated) of PreproET-1 in kidney medulla associated with medulla
6) Confidence 0.31 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0 Pain Relevance 0.09
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Phosphorylation (phosphorylation) of ET-1 in kidney medulla associated with medulla and diabetes mellitus
7) Confidence 0.24 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.66 Pain Relevance 0.08
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Phosphorylation (phosphorylation) of ET-1 in kidney cortex associated with medulla and diabetes mellitus
8) Confidence 0.24 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.66 Pain Relevance 0.08
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Phosphorylation (phosphorylated) of ET-1 in kidney cortex associated with medulla
9) Confidence 0.24 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
We observed an up-regulation of inducible nitric oxide synthase (iNOS), prepro endothelin-1 (preproET-1) and phosphorylated p38-MAPK in thoracic aorta and kidney cortex but not in kidney medulla in 28-days diabetes group.


Neg (not) Phosphorylation (phosphorylated) of endothelin-1 in kidney cortex associated with medulla and diabetes mellitus
10) Confidence 0.18 Published 2005 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC555576 Disease Relevance 1.03 Pain Relevance 0.09
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Phosphorylation (phosphorylated) of preproET-1 in kidney medulla associated with medulla
11) Confidence 0.18 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.40 Pain Relevance 0.11
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Phosphorylation (phosphorylated) of preproET-1 in thoracic aorta associated with medulla
12) Confidence 0.18 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.40 Pain Relevance 0.11
We observed an up-regulation of inducible nitric oxide synthase (iNOS), prepro endothelin-1 (preproET-1) and phosphorylated p38-MAPK in thoracic aorta and kidney cortex but not in kidney medulla in 28-days diabetes group.


Neg (not) Phosphorylation (phosphorylated) of preproET-1 in kidney cortex associated with medulla and diabetes mellitus
13) Confidence 0.18 Published 2005 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC555576 Disease Relevance 1.02 Pain Relevance 0.09
PreproET-1, iNOS, eNOS, total and phosphorylated p38-MAPK and ERK protein expressions of thoracic aorta, kidney cortex and kidney medulla were determined using standard SDS-PAGE and immunoblot technique.
Phosphorylation (phosphorylated) of PreproET-1 in kidney cortex associated with medulla
14) Confidence 0.11 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0 Pain Relevance 0.09
PreproET-1, iNOS, eNOS, total and phosphorylated p38-MAPK and ERK protein expressions of thoracic aorta, kidney cortex and kidney medulla were determined using standard SDS-PAGE and immunoblot technique.
Phosphorylation (phosphorylated) of PreproET-1 in thoracic aorta associated with medulla
15) Confidence 0.11 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0 Pain Relevance 0.09
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Phosphorylation (phosphorylated) of ET-1 in thoracic aorta associated with medulla
16) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Phosphorylation (phosphorylated) of ET-1 in kidney medulla associated with medulla
17) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11

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