INT18158

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.45
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nephron 2
nerve 2
vesicles 2
PSP 2
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 17 99.76 Very High Very High Very High
sodium channel 16 97.84 Very High Very High Very High
nMDA receptor 9 97.52 Very High Very High Very High
antagonist 18 97.44 Very High Very High Very High
conotoxin 12 97.12 Very High Very High Very High
narcan 2 96.80 Very High Very High Very High
opiate 3 86.24 High High
Glutamate 30 84.76 Quite High
ischemia 12 79.04 Quite High
gABA 7 71.28 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 11 100.00 Very High Very High Very High
Death 30 99.80 Very High Very High Very High
Natriuresis 11 99.72 Very High Very High Very High
Shellfish Poisoning 52 99.02 Very High Very High Very High
Diuresis 14 98.04 Very High Very High Very High
Apoptosis 39 94.20 High High
Cv Unclassified Under Development 12 79.04 Quite High
Reperfusion Injury 1 78.24 Quite High
Injury 3 75.00 Quite High
Acidosis 1 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of Na+ pump sites identified by [3H]ouabain binding binding declined with decreasing levels of Na+ in the medium in a time-dependent manner over 48 h, with a concomitant increase in cellular Na+ content.
Negative_regulation (declined) of Positive_regulation (increase) of Na
1) Confidence 0.36 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3942206 Disease Relevance 0 Pain Relevance 0.10
In the presence of ouabain, both diuretics decreased net intracellular accumulation of Na+, but caused no change in K+ content.
Negative_regulation (decreased) of Positive_regulation (accumulation) of Na
2) Confidence 0.36 Published 1996 Journal Acta Physiol. Scand. Section Abstract Doc Link 8899058 Disease Relevance 0 Pain Relevance 0.07
Both Na+ flux mechanisms appear to operate in a single population of vesicles since opening of the Na+ channel with veratridine diminishes the ATP-dependent accumulation of Na+ by over 75%.
Negative_regulation (diminishes) of Positive_regulation (accumulation) of Na in vesicles
3) Confidence 0.29 Published 1982 Journal J. Biol. Chem. Section Abstract Doc Link 6286677 Disease Relevance 0 Pain Relevance 0.19
Perfusion of nerve segments with zero-Na+/Li(+)-substituted medium and Na+ channel blockade by tetrodotoxin (1 microM) prevented anoxia-induced increases in Na and Ca concentrations of axoplasm and mitochondria.
Negative_regulation (prevented) of Positive_regulation (increases) of Na in nerve associated with tetrodotoxin and hypoxia
4) Confidence 0.12 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8592118 Disease Relevance 0.41 Pain Relevance 0.16
In this study, marked natriuresis (in terms of increased urinary Na+ level and sodium saliuretic index) was evident possibly because of the inhibition of Na+ resorption in the nephron,[4] thereby increasing the urinary output.
Spec (possibly) Negative_regulation (inhibition) of Positive_regulation (increased) of Na in nephron associated with natriuresis
5) Confidence 0.08 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992138 Disease Relevance 0.33 Pain Relevance 0
Previous injection of FK-33824 (100 ng) into the LH increased the antidiuretic effect of carbachol, but blocked the increase in Na+ excretion and decreased K+ excretion.
Negative_regulation (blocked) of Positive_regulation (increase) of Na
6) Confidence 0.07 Published 1990 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 1966129 Disease Relevance 0 Pain Relevance 0.34
PSP toxins are now regarded as blocking agents that reduce the number of conducting Na+ channels by occupying some site near the outer opening in a 1:1 high affinity specific receptor binding.
Negative_regulation (reduce) of Positive_regulation (conducting) of Na in PSP associated with shellfish poisoning
7) Confidence 0.04 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 0.23 Pain Relevance 0.22
Downstream of the KATP channel, inhibition of voltage-gated Na+ (TTX) and N-type Ca2+ channels (?
Negative_regulation (inhibition) of Positive_regulation (gated) of Na
8) Confidence 0.03 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.12
The occurrence of a single additional drinking bout (forced drinking) at the onset of the sleeping period (Figure 4F, dotted line 1) delays the increase in ECF [Na+] (Figure 4A, gray line), compared to the absence of additional drinking bout (Figure 4A, black line).
Negative_regulation (delays) of Positive_regulation (increase) of Na
9) Confidence 0.01 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0 Pain Relevance 0
This AVP-induced increase in urinary Na+ loss was abolished in animals receiving combined AVP (0.04 pmol.min-1) and AVP V1 antagonist (674 +/- 47 mumol, n = 7) although the antidiuretic effect persisted.
Negative_regulation (abolished) of Positive_regulation (increase) of Na associated with antagonist
10) Confidence 0.01 Published 1997 Journal Ren Fail Section Abstract Doc Link 9044449 Disease Relevance 0 Pain Relevance 0.13
Neuroprotective concepts for POAG aim at protecting RGCs from the initiating, extracellular cell death signals, reduce increased Na+ and Ca2+ influx into the cell directly or to block specific NMDA receptors, and on agents which block the intracellular signal cascade for RGC apoptosis (e.g. inhibition of excessive free radical formation) [44, 112, 126, 127, 132, 152, 158].
Negative_regulation (reduce) of Positive_regulation (increased) of Na associated with nmda receptor, apoptosis and death
11) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.47 Pain Relevance 0.13

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