INT181581

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.76
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
thoracic aorta 4
vasculature 1
kidney cortex 1
kidney medulla 1
carotid artery 1
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 2 100.00 Very High Very High Very High
medulla 57 96.16 Very High Very High Very High
agonist 1 93.52 High High
Bioavailability 8 60.36 Quite High
fibrosis 1 52.88 Quite High
Inflammation 8 22.16 Low Low
Kinase C 10 19.92 Low Low
antagonist 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 2 100.00 Very High Very High Very High
Diabetes Mellitus 425 99.86 Very High Very High Very High
Increased Venous Pressure Under Development 27 95.68 Very High Very High Very High
Pressure And Volume Under Development 18 82.16 Quite High
Stress 21 81.48 Quite High
Hyperglycemia 30 80.56 Quite High
Congenital Anomalies 12 80.52 Quite High
Diabetic Angiopathy 1 79.76 Quite High
Injury 3 78.04 Quite High
Sepsis 7 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Neg (NO) Regulation (alter) of Positive_regulation (activation) of ET-1 in thoracic aorta associated with medulla and diabetes mellitus
1) Confidence 0.23 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.73 Pain Relevance 0.08
plays critical roles in the vasculature, in particular on endothelium-dependent relaxation.36 Migraine is associated with a specific vascular risk profile assessed as vascular dysfunction, compared with normal control; in patients with migraine the systolic blood pressure, diastolic blood pressure, blood glucose, and insulin are increased in association with an elevated ET-1 and an increased carotid artery intima thickness, which coincides with a reverse relation to flow-mediated vasodilation.37 As an indicator for early vascular abnormality in diabetes, the carotid intima-media thickness (IMT) is significantly greater in diabetics without macroangiopathy compared with the normal control, and the increased IMT is significantly progressive over a 30-month follow-up period in diabetics but not in the controls.38

Hypertension and stress-induced vascular abnormalities

Regulation (roles) of in vasculature Positive_regulation (elevated) of ET-1 in carotid artery associated with stress, pressure and volume under development, congenital anomalies, diabetes mellitus, migraine and increased venous pressure under development
2) Confidence 0.15 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.58 Pain Relevance 0.27
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Neg (NO) Regulation (alter) of in kidney cortex Positive_regulation (activation) of ET-1 in thoracic aorta associated with medulla and diabetes mellitus
3) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.73 Pain Relevance 0.08
Therefore, the specific aims of the study are to characterize the progression of STZ-induced renal and vascular dysfunction at 14- and 28-days; and to examine if the progression of STZ-induced diabetes would alter the biosynthesis and activation of ET-1, NO and the phosphorylation of p38-MAPK and ERK1/2 in thoracic aorta, kidney cortex and kidney medulla.


Neg (NO) Regulation (alter) of in kidney medulla Positive_regulation (activation) of ET-1 in thoracic aorta associated with medulla and diabetes mellitus
4) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.73 Pain Relevance 0.08

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