INT181587

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.36
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OPN1SW) plasma membrane (OPN1SW) signal transducer activity (OPN1SW)
Anatomy Link Frequency
fertilized egg 1
skin 1
body 1
OPN1SW (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 29 99.52 Very High Very High Very High
imagery 12 87.20 High High
agonist 8 83.44 Quite High
Clonidine 1 82.12 Quite High
Serotonin 14 76.96 Quite High
noradrenaline 2 76.16 Quite High
sNRI 4 73.36 Quite High
Duloxetine 1 72.72 Quite High
Neurotransmitter 9 72.24 Quite High
depression 97 69.12 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 77 100.00 Very High Very High Very High
Cognitive Disorder 69 100.00 Very High Very High Very High
Obesity 36 100.00 Very High Very High Very High
Weight Gain 2 100.00 Very High Very High Very High
Sleep Disorders 128 97.48 Very High Very High Very High
Dyspnea 2 95.92 Very High Very High Very High
Fatigue 82 93.44 High High
Disease 13 92.76 High High
Generalized Anxiety Disorder 24 90.00 High High
Chronic Fatigue Syndrome 13 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subjects 5 showed a slight decrease in CBT from before (M = 98.12, SD = 0.14) to after the subject returned to the bed (M = 97.91, SD = 0.08), t(3) = -5.17, p = .014).
Negative_regulation (decrease) of CBT
1) Confidence 0.51 Published 2005 Journal J Circadian Rhythms Section Body Doc Link PMC555580 Disease Relevance 0 Pain Relevance 0
It is therefore important to study factors which have prevented CBT from gaining popularity in Pakistan.
Negative_regulation (prevented) of CBT
2) Confidence 0.50 Published 2010 Journal Int J Ment Health Syst Section Body Doc Link PMC2831026 Disease Relevance 0.35 Pain Relevance 0.08
Therefore, CBT declines remain a plausible explanation for the portion of the 24 hours when CBFV declined.
Negative_regulation (declines) of CBT
3) Confidence 0.37 Published 2005 Journal J Circadian Rhythms Section Body Doc Link PMC555580 Disease Relevance 0.24 Pain Relevance 0.03
After 12 weeks of open-label therapy, the CBT intervention will be reduced to one session per month during the long-term phase of the trial.
Negative_regulation (reduced) of CBT
4) Confidence 0.27 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2877665 Disease Relevance 0.35 Pain Relevance 0
Claudino and colleagues16 evaluated the efficacy of adjunctive treatment with topiramate compared to that with placebo in reducing weight gain and binge eating in obese patients receiving cognitive behavior therapy (CBT).
Negative_regulation (reducing) of CBT associated with cognitive disorder, obesity, weight gain and eating disorder
5) Confidence 0.19 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2714287 Disease Relevance 1.02 Pain Relevance 0.06
Specifically, the authors point to the reduced efficacy of melatonin function during the LP, which results in a blunted nocturnal decline of CBT and reduced circadian CBT amplitude, as a stabilizing factor which would encourage proper implantation and development of a fertilized egg [35].
Negative_regulation (decline) of CBT in fertilized egg
6) Confidence 0.12 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0
Specifically, under entrained conditions, the late evening rise in circulating melatonin levels triggers a thermoregulatory cascade, which, via an increase in the blood flow through distal skin regions and a subsequent decrease in core body temperature (CBT), favors sleep initiation (Figure 3) [21].
Negative_regulation (decrease) of CBT in body
7) Confidence 0.12 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0 Pain Relevance 0
Most notably, during the LP compared to the FP, there is an increase of ~0.3–0.4°C in CBT levels (Figure 4) [35, 36] as well as a significant reduction in the amplitude of the circadian variation of CBT [35–38], owing mainly to a blunted nocturnal decline of CBT.
Negative_regulation (decline) of CBT
8) Confidence 0.12 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.17 Pain Relevance 0
Exogenous melatonin administered during the day (when endogenous levels are low) reduces CBT and increases skin temperature, with concomitant increases in sleepiness [27].
Negative_regulation (reduces) of CBT in skin associated with sleep disorders
9) Confidence 0.12 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817387 Disease Relevance 0.18 Pain Relevance 0
(5) What is the cost-effectiveness of exercise therapy and CBT compared to usual care?


Negative_regulation (effectiveness) of CBT
10) Confidence 0.07 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2821386 Disease Relevance 0.96 Pain Relevance 0
Patients show a specific “cognitive bias” with increased attention to threat-related information and misinterpretation of ambiguous stimuli as threatening, and this bias has been shown to diminish with cognitive-behaviour therapy (CBT) and after selective serotonin reuptake inhibitor (SSRI) treatment (Mogg et al 1995, 2004).
Negative_regulation (diminish) of CBT associated with cognitive disorder and ssri
11) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654626 Disease Relevance 0.60 Pain Relevance 0.72
However, evidence for the effectiveness of CBT in patients FSHD is not yet available.
Negative_regulation (effectiveness) of CBT
12) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.49 Pain Relevance 0

General Comments

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