INT181614

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.18
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TDO2) small molecule metabolic process (TDO2) oxidoreductase activity (TDO2)
cellular nitrogen compound metabolic process (TDO2)
Anatomy Link Frequency
liver 1
TDO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 96.48 Very High Very High Very High
cytokine 1 89.80 High High
depression 13 77.56 Quite High
Catecholamine 2 45.52 Quite Low
Dopamine 3 31.44 Quite Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
noradrenaline 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 99.82 Very High Very High Very High
Sclerosis 1 92.72 High High
Disease 45 92.28 High High
Celiac Disease 44 91.96 High High
Syndrome 11 88.24 High High
Amelogenesis Imperfecta 81 86.96 High High
Depression 36 77.56 Quite High
Congenital Anomalies 6 58.40 Quite High
Affective Disorder 2 54.08 Quite High
Open Bite 4 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[30] and, for instance, such events as a stress-related increase in liver tryptophan pyrrolase enzyme activity [23], may lead to lowered tryptophan levels by the enhanced tryptophan catabolism induced by increased activity of the kynurenine-niacin pathway [30-32], even without malabsorption.


Positive_regulation (increase) of tryptophan pyrrolase in liver associated with stress
1) Confidence 0.45 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC555756 Disease Relevance 1.18 Pain Relevance 0.18
TDO is caused by a mutation in the DLX3 gene [50].
Positive_regulation (caused) of TDO
2) Confidence 0.08 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1853073 Disease Relevance 1.00 Pain Relevance 0

General Comments

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