INT181619

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ACE, KNG1) extracellular region (ACE, KNG1) plasma membrane (ACE, KNG1)
endosome (ACE) peptidase activity (ACE)
ACE (Homo sapiens)
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 22 100.00 Very High Very High Very High
Glutamate receptor 1 76.48 Quite High
cva 4 75.12 Quite High
gABA 1 72.84 Quite High
Inflammation 8 62.24 Quite High
antagonist 10 59.68 Quite High
headache 3 9.80 Low Low
Migraine 5 8.64 Low Low
Pain 10 5.00 Very Low Very Low Very Low
beta blocker 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 22 94.72 High High
Apoptosis 4 85.48 High High
Coronary Heart Disease 2 83.04 Quite High
Injury 4 81.12 Quite High
Myocardial Infarction 11 78.68 Quite High
Ventricular Remodeling 2 77.56 Quite High
Thrombosis 1 75.12 Quite High
Disease 14 68.40 Quite High
Stress 15 63.60 Quite High
INFLAMMATION 9 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE-I also modulate the vascular fibrinolytic balance by decreasing Ang II, a potent activator of plasminogen activator inhibitor type 1 (PAI-1) synthesis, and by increasing levels of bradykinin, a potent activator for tissue plasminogen (Vaughan 1997).
ACE-I Positive_regulation (increasing) of bradykinin associated with bradykinin
1) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.60 Pain Relevance 0.20
bradykinin, ACEIs may increase cardiac NO levels via
ACEI Neg (NO) Spec (may) Positive_regulation (increase) of bradykinin associated with bradykinin
2) Confidence 0.08 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.37 Pain Relevance 0.38

General Comments

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